Indications

Xelpid EZ is indicated as an adjunct to diet and lifestyle modification for managing high cholesterol and reducing cardiovascular risk.

Primary Hyperlipidemia Used to reduce:

Total Cholesterol (TC)
LDL Cholesterol (LDL-C)
Apolipoprotein B (Apo B)
Triglycerides (TG)
Non-HDL Cholesterol

And to increase:

HDL Cholesterol (HDL-C)

Indicated for patients with:

Heterozygous familial hyperlipidemia
Non-familial hyperlipidemia
Mixed hyperlipidemia

Homozygous Familial Hypercholesterolemia (HoFH) Used to reduce elevated Total Cholesterol and LDL Cholesterol as an adjunct to other lipid-lowering therapies (e.g., LDL apheresis) or when such therapies are unavailable.

Pharmacology

Atorvastatin

Inhibits HMG-CoA reductase, reducing hepatic cholesterol synthesis.
Increases LDL receptors in the liver.
Enhances removal of LDL cholesterol from circulation.
Reduces LDL production.

Ezetimibe

Blocks intestinal cholesterol absorption by inhibiting the NPC1L1 transporter.
Reduces delivery of cholesterol to the liver.
Decreases hepatic cholesterol stores.
Increases cholesterol clearance from blood.
Complements the action of statins through a different mechanism.

Dosage & Administration

Recommended Dose Range

10/10 mg to 80/20 mg once daily

Starting Dose

10/10 mg once daily
20/10 mg once daily

Patients requiring >55% LDL-C reduction

40/10 mg once daily

Administration:

May be taken at any time of day.
Can be taken with or without food.

Lipid profile should be evaluated within 2 weeks or more after initiation or dose adjustment.

Homozygous Familial Hypercholesterolemia

40/10 mg daily or
80/10 mg daily

Drug Interactions

Use caution or avoid concomitant use with:

Cyclosporine
Gemfibrozil
Niacin (high doses)
Clarithromycin
HIV protease inhibitors
Itraconazole
Colchicine
Warfarin (monitor INR)
Digoxin (monitor levels)

May increase plasma levels of:

Norethindrone
Ethinyl estradiol

Contraindications

Active liver disease
Unexplained persistent elevation of liver enzymes (transaminases)
Hypersensitivity to atorvastatin, ezetimibe, or any component of the formulation