Dosage

The recommended dosage regimen is- Vonoprazan 20 mg Amoxicillin 1000 mg Clarithromycin 500 mg Each given twice daily (morning and evening, 12 hours apart), with or without food, for 14 days. Geriatrics: The standard triple therapy regimen increased risk of torsade de pointes due to the clarithromycin component. Renal Impairment: Avoid use in severe renal impairment. Hepatic Impairment: Avoid use in moderate and severe hepatic impairment. Take medicine as per doctor's advice.

Interaction

Triple therapy regimen should be used with caution when co-administrated with following drugs: Tacrolimus, cyclosporine, clopidogrel, citalopram, cilostazol, probenecid, allopurinol, itraconazole, ketoconazole, erlotinib, dasatinib, nilotinib, mycophenolate mofetil, saquinavir, ritonavir, etravirine, rilpivirine-containing products, atazanavir, nelfinavir.

Contraindications

The standard triple therapy regimen is contraindicated in patients with known hypersensitivity to vonoprazan, amoxicillin or any other betalactams, clarithromycin or any other macrolide antimicrobials

Side Effects

Side Effects

Precautions

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Overdose Effects

If overdose occurs, should consult with doctor immediately.

Storage Conditions

Do not store above 30°C. Keep in a dry place. Protect from light and keep out of the reach of children.

Safety Advice

UNSAFE – Alcohol: Consuming alcohol while taking Vonoprazan + Amoxicillin + Clarithromycin\n may cause symptoms such as flushing, increased heart beat, nausea, thirst, chest pain and low blood pressure (Disulfiram reaction).
CONSULT YOUR DOCTOR – Pregnancy: Based on findings from animal studies and observational studies in pregnant women with use of clarithromycin, use of this triple pack is not recommended in pregnant women except in clinical circumstances where no alternative therapy is appropriate.
SAFE IF PRESCRIBED – Breastfeeding: There are no data regarding the presence of vonoprazan in human milk, the effects on the breastfed infant or the effects on milk production. Vonoprazan and its metabolites are present in animal study
UNSAFE – Driving: Vonoprazan + Amoxicillin + Clarithromycin may cause side effects which could affect your ability to drive. Pylotrip can have side effects and the symptoms (such as allergic reactions, dizziness and convulsions) may make you unfit to drive.
CAUTION – Kidney: Vonoprazan + Amoxicillin + Clarithromycin\n should be used with caution in patients with kidney disease. Dose adjustment of Pylotrip may be needed. Please consult your doctor. Use of this medicine is not recommended in patients with severe kidney disease.
CONSULT YOUR DOCTOR – Liver: Vonoprazan + Amoxicillin + Clarithromycin is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Pylotrip may not be needed in these patients.