Indications Coenzyme Q10 is indicated in:

Infertility

Neurological disorders

Cardiovascular disease

Others

Pharmacology

Coenzyme Q10 (Ubidecarenone) is a fat‑soluble vitamin‑like substance present in every cell.
Acts as a vital intermediate in the electron transport system of mitochondria for cellular respiration and ATP production.
Highest requirement in metabolically active tissues: heart, immune system, skeletal muscle, gingiva.
Production decreases with age, contributing to aging.
Absorption is better with lipid‑rich food. After oral intake, absorbed via small intestine → lymphatic system → liver → incorporated into lipoproteins → blood circulation → tissues.
Distributed to heart, muscle, liver, kidney, brain.
Metabolized in all tissues; ~60% excreted in feces, mainly eliminated via bile.

Dosage & Administration

Dividing total daily dose into smaller amounts reduces side effects.

Interaction

Statins: reduce endogenous CoQ10; supplementation restores levels.
Warfarin: may reduce effectiveness.
Beta‑blockers (esp. propranolol): may inhibit CoQ10‑dependent enzymes.
Antidiabetic medications: may improve glycemic control; dose adjustment may be needed.
Doxorubicin: may reduce cardiotoxicity.