Indications

DK 4000 Capsule is indicated for:

Supporting cardiovascular health
Contributing to the normal absorption and utilization of calcium and phosphorus in the body
Contributing to normal blood clotting
Helping maintain normal bone health

Composition

Each softgel capsule contains:

Vitamin D3 (Cholecalciferol) 4000 IU
Vitamin K2 100 mcg

Pharmacology

Vitamin K2

Vitamin K2 is essential for the activation of osteocalcin, a protein responsible for transporting and integrating calcium into bones, helping to maintain a healthy skeleton. By directing calcium into the bone matrix, Vitamin K2 helps reduce the deposition of calcium in soft tissues.

Vitamin D3 (Cholecalciferol)

Vitamin D3 plays a vital role in normal bone growth and development and helps maintain bone density. It also assists the body in utilizing calcium and phosphorus effectively.

The active form of Vitamin D3, calcitriol, exerts its effects through binding to Vitamin D Receptors (VDRs), which are widely distributed throughout body tissues.

Vitamin D3 is a fat-soluble vitamin with a half-life of approximately 50 days. It is absorbed in the small intestine, binds to specific α-globulins, and is transported to the liver, where it is metabolized into 25-hydroxyvitamin D3 (calcidiol). A second hydroxylation occurs in the kidneys, producing 1,25-dihydroxyvitamin D3 (calcitriol), the biologically active form responsible for increasing calcium absorption.

Unmetabolized Vitamin D3 is stored in fat and muscle tissues and is eliminated through feces and urine.

Dosage and Administration

Adults and children over 12 years of age:

1 to 2 capsules daily, or
As directed by a registered physician

Drug Interactions

Vitamin K2

May antagonize the effects of coumarin-type anticoagulants (e.g., warfarin).
Concomitant use of anticonvulsants may reduce the effectiveness of Vitamin K.

Vitamin D3 (Cholecalciferol)

May interact with:

Carbamazepine
Dactinomycin
Diuretics
Fosphenytoin
Miconazole
Phenobarbital
Phenytoin
Primidone

Contraindications

Contraindicated in patients with known hypersensitivity to any of the ingredients.

Side Effects

Generally well tolerated when used at the recommended dosage.

Pregnancy and Lactation

Vitamin K2 and Vitamin D3 are considered safe during pregnancy and lactation when used at recommended doses.

Therapeutic Class

Nutraceuticals
Vitamin and Mineral Supplements

Storage Conditions

Store in a cool and dry place below 30°C.
Protect from direct sunlight and moisture.
Do not freeze.
Keep out of the reach of children.