Indications

Fexonor (Fexofenadine Hydrochloride) is indicated for:

Allergic Rhinitis For the relief of symptoms associated with seasonal and perennial allergic rhinitis in adults and children aged 12 years and above.

Symptoms effectively treated include:

Sneezing
Runny nose (rhinorrhea)
Excessive tearing (lacrimation)
Itchy, red, watery eyes
Itching of the nose, palate, and throat

Chronic Idiopathic Urticaria

Relief of itching (pruritus)
Reduction of wheals and skin rashes associated with chronic idiopathic urticaria (hives)

Pharmacology

The H1 histamine receptor plays a key role in allergic and hypersensitivity reactions. When the body is exposed to allergens, mast cells and basophils release histamine and other inflammatory mediators. Histamine then binds to H1 receptors, triggering allergic symptoms such as itching, runny nose, watery eyes, and sneezing.

Fexofenadine is an H1-receptor antagonist (inverse agonist) that selectively binds to H1 receptors and prevents their activation. It has:

Potent antihistamine activity
High selectivity for H1 receptors
No significant anticholinergic activity
No significant antidopaminergic or antiserotonergic activity
No sedative effect

Fexofenadine does not significantly cross the blood-brain barrier and therefore is unlikely to cause drowsiness or central nervous system effects.

Dosage & Administration

Allergic Rhinitis

Adults and Children (12 years and above)

Tablet: 60 mg twice daily, or
120 mg once daily, or
180 mg once daily

Patients with Renal Impairment

60 mg once daily

Children (6-11 years)

Tablet: 30 mg twice daily or 60 mg once daily
Renal impairment: 30 mg once daily

Children (2-11 years)

Suspension: 30 mg (5 ml) twice daily
Renal impairment: 30 mg (5 ml) once daily

Chronic Idiopathic Urticaria

Adults and Children (12 years and above)

Tablet: 60 mg twice daily, or
120 mg once daily, or
180 mg once daily

Patients with Renal Impairment

60 mg once daily

Children (6-11 years)

Tablet: 30 mg twice daily or 60 mg once daily
Renal impairment: 30 mg once daily

Children (6 months to below 2 years)

Suspension: 15 mg (2.5 ml) twice daily
Renal impairment: 15 mg (2.5 ml) once daily

Children (2-11 years)

Suspension: 30 mg (5 ml) twice daily
Renal impairment: 30 mg (5 ml) once daily

Drug Interactions

Erythromycin and Ketoconazole: May increase blood levels of fexofenadine by 2-3 times.
Omeprazole: No significant interaction observed.
Aluminium and Magnesium-containing Antacids: May reduce the absorption and bioavailability of fexofenadine.
It is recommended to maintain a 2-hour interval between Fexonor and antacids containing aluminium or magnesium hydroxide.