Indications

Synogen Plus is indicated in:
Osteoarthritis
. Rheumatoid arthritis
. Joint pain & inflammation
. Difficulties in flexibility & mobility
. Joint discomfort & stiffness (knee extension)
Impaired joint function
. Strenuous exercise & sports

Composition

Each capsule contains-
. Undenatured Type-II Collagen 40 mg
. Glucosamine Hydrochloride 150 mg
. Chondroitin Sulfate 120 mg

Pharmacology

Glucosamine is a naturally occurring amino sugar of cartilage that provides the basic raw material needed by the body to manufacture joint cartilage. Chondroitin is another naturally occurring
mucopolysaccharide of cartilage that stimulates cartilage production, inhibits cartilage destroying enzymes, draws fuid to the cells and helps lubricate the joints. Glucosamine and Chondroitin work
synergistically together to help stimulate the production and regeneration of connective tissues (e.g., cartilage, bone, tendon, skin, mucous membrane, blood vessels etc.). Undenatured Type II Collagen
is derived from chicken sternum cartilage using a patented, low temperature, nonenzymatic manufacturing process that preserves the natural triple helix molecular confguration and its biological
activity. Undenatured Type II Collagen molecules contain active binding sites called epitopes which trigger the process of oral tolerization. Through oral tolerization process, active epitopes of
Undenatured Type II Collagen interact with Peyer's patches (lymphoid tissue) of small intestine to release collagen-specifc regulatory T-cells. Collagen-specifc regulatory T-cells then migrate to joint
areas and prevent release of T-cells which are destructive for joint cartilage. It prevents the secretion of collagenase enzymes by macrophages responsible for breakdown of collagen in joint cartilage. It
also slows the production of infammatory cytokines resulting in reduction of infammation, halting the erosion of joint cartilage and
promote cartilage rebuilding.

Dosage & Administration

1 tablet or capsule daily with meal or as directed by the physician. The safety and effectiveness under the age of 18 years have not been established.

Interaction

There is no known drug interaction with Undenatured type II Collagen, Glucosamine and Chondroitin.

Contraindications

This combination is contraindicated in patients with known hypersensitivity to Glucosamine, Chondroitin, chicken or egg.

Side Effects

Undenatured Type II Collagen, Glucosamine & Chondroitin are well tolerated in recommended dose. Side effects are rare and some may feel stomach problems.

Pregnancy & Lactation

No studies have evaluated the use of Undenatured Type II Collagen, Glucosamine and Chondroitin during pregnancy or lactation. It should be taken with caution and medical advice during pregnancy
and lactation.