Indication

Adult: PO Gastric Hyperacidity, Heartburn: Up to 1 g/day. \r\n\r\nHyperphosphataemia in chronic renal failure Up to 10 g/day in divided doses w/ meals.\r\n\r\n10-20 mL PO between meals & qHS

Administration

Aluminium Hydroxide: Enhanced absorption with citrates or ascorbic acid. Decreases absorption of allopurinol, tetracyclines, quinolones, cephalosporins, biphosphonate derivatives, corticosteroids, cyclosporin, delavirdine, Fe salts, imidazole antifungals, isoniazid, mycophenolate, penicillamine, phosphate supplements, phenytoin, phenothiazines, trientine.\r\n\r\nMagnesium Hydroxide: Decreases absorption of tetracyclines and biphosphonates. Separate administration of these and other drugs by around 2 hr.

Adult Dose

Chronic renal impairment; CHF; oedema; cirrhosis and low Na diets; patients with recent GI haemorrhage. Administer 2-3 hrs before/after another medication to minimise drug interactions. Pregnancy and lactation.\r\n\r\nLactation: excretion in milk unknown; use caution

Renal Dose

Alumunium hydroxide acts on the HCl in the stomach by neutralization, forming aluminium chloride salt and water.\r\nMagnesium hydroxide increases peristaltic activity causing osmotic retention of fluids, thus resulting in bowel evacuation. It also reduces stomach acid by reacting with hydrochloric acid to form Mg chloride.\r\n

Mode of Action

May be taken with or without food.

Precaution

Heartburn, Reflux oesophagitis, Hyperacidity, Peptic ulcer, Constipation, Indigestion

Pregnancy Category Note

>10%\r\nAluminum oxide,Chalky taste,Constipation,Fecal impaction,Stomach cramps\r\n\r\nFrequency Not Defined\r\nAluminum oxide,Nausea,Vomiting,Aluminum intoxication,Hypophosphatemia,Osteomalacia,Magnesium oxide,Diarrhea,Hypermagnesemia

Interaction

Hypersensitivity to aluminium salts.