Ticoplan is indicated in adults and in children of the following infections-
. Complicated skin and soft tissue infections
. Bone and joint infections
. Hospital-acquired pneumonia
. Community-acquired pneumonia
. Complicated urinary tract infections
. Infective endocarditis

Ticoplan is also indicated as an alternative oral treatment for Clostridium difficile infection-associated diarrhoea and colitis. Where appropriate, Ticoplan should be administered in
combination with other antibacterial agents.

Pharmacology

Teicoplanin is a glycopeptide-antibiotic produced by Actinoplanes teichomyceticus. It is presented as a sterile, pyrogen-free ivory white powder for reconstitution with water for
injection. It is freely soluble in water and on reconstitution gives a clear solution. Teicoplanin inhibits the growth of susceptible organisms by interfering with cell-wall biosynthesis at a
site different from that affected by beta-lactams. Peptidoglycan synthesis is blocked by specific binding to D-alanyl-D-alanine residues.

Dosage & Administration

Teicoplanin can be given intravenously (as a bolus injection or infusion) or intramuscularly. The intravenous injection may be administered either as a bolus over 3 to 5 minutes or as a
30-minute infusion. Only the infusion method should be used in neonates. It should be given once daily after one or more loading doses. The dosage of Teicoplanin should be adapted
on the severity of the infection and patient's response to treatment.

In adults (Normal kidney function):
. On the first day, a dose of 6 mg/kg (generally 400 mg) intravenously is recommended. On the following days, the dose may be 6 mg/kg/day (generally 400 mg) intravenously or 3
mg/kg/day (generally 200 mg) intravenously or intramuscularly as a single daily dose. The highest dose and the intravenous route are recommended for serious infections.
. In potentially fatal infections, treatment should be started with 6 mg/kg (usually 400 mg) twice daily for 1 to 4 days (loading dose) and continued with 6 mg/kg/day intravenously