Indications

Flemo Max capsule is indicated for-
Osteoarthritis
. Rheumatoid arthritis
. Joint pain & infammation
. Difculties in fexibility & mobility
. Joint discomfort & stifness (knee extension)

Composition

Each capsule contains-
Undenatured Type-II Collagen 20 mg
. Hyaluronic Acid 35 mg
Methylsulfonylmethane 200 mg
. Turmeric Extract 50 mg (18% curcuminoids)
· Boswellia serrata Extract 50 mg (30% AKBA)

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Pharmacology

Undenatured Type II Collagen is derived from chicken sternum cartilage using a patented, low-temperature, nonenzymatic manufacturing process that preserves the natural triple helix molecular
confguration and its biological activity.

It contains active binding sites called epitopes which trigger the process of oral tolerization. Through oral tolerization process, active epitopes of Undenatured Type II Collagen interact with Peyer's
patches (lymphoid tissue) of small intestine to release collagen-specifc regulatory T-cells. Collagen-specifc regulatory T-cells then migrate to joint areas and prevent release of T-cells which are
destructive for joint cartilage.

It prevents the secretion of collagenase enzymes by macrophages responsible for breakdown of collagen in joint cartilage. It also slows the production of infammatory cytokines resulting in reduction of
infammation, halting the erosion of joint cartilage and promote cartilage rebuilding.

Hyaluronic acid is naturally present throughout the human body. In the joints, hyaluronic acid has several functions, including:

Lubrication: Hyaluronic acid binds well to water, producing a viscous, jelly-like consistency. This viscous fuid provides lubrication and also acts as a shock absorber within the joint. Growth of cartilage
and bone: Hyaluronic acid helps in the growth and development of joint's cartilage and bone by promoting the growth of new cells and tissues. Reducing infammation: Hyaluronic acid plays an
important role in reducing joint infammation and pain caused by injury or tissue degeneration.

Methylsulfonylmethane (MSM) has anti-infammatory and antioxidant efects. Sulphur, which is a major component of MSM, plays an important role in making collagen and glucosamine, both of which
are vital for healthy bones and joints. In clinical study, MSM shows signifcant decrease in WOMAC pain and physical function impairment.

Turmeric extract contains curcumin which has anti-infammatory, antithrombotic, antioxidant, and antimicrobial activities. The anti-infammatory efects of curcumin are believed to be a result of
inhibiting pro-infammatory signals such as prostaglandins, leukotrienes, and cyclooxygenase-2. In addition, curcumin has been demonstrated to suppress several pro-infammatory cytokines and
mediators of their release such as tumor necrosis factor-a (TNF-a), IL-1, IL-8, and nitric oxide synthase.

Boswellic acid is the active ingredient in Boswellia serrata which has signifcant pharmacological activity in the treatment of infammatory diseases such as rheumatoid arthritis and other infammatory
conditions. Research showed that 3-0-Acetyl-11-keto-beta-boswellic acid (AKBA), present in Boswellia serrata extract, has a powerful inhibitory efect on 5-lipoxygenase (5-LOX).

Dosage & Administration

One capsule two times daily with meal or as directed by the physician. The safety and effectiveness under the age of 18 years have not been established.

Interaction

There is no known drug interaction with Undenatured type II Collagen, Hayaluronic Acid, Methylsulfonylmethane, Turmeric Extract and Boswellia serrata Extract