Indication

Diarrhea, nausea, heartburn, indigestion, upset stomach.

Administration

Drink plenty of clear fluids to prevent dehydration caused by diarrhea\r\n\r\nDo not use for >2 days\r\n

Adult Dose

Adult: 30 ml 3-4 times daily 30 mintues before meal.

Child Dose

Child: 3-12 years: 5-15 ml\r\n<3 years: Safety and efficacy not established

Contraindication

Hypersensitivity to bismuth, aspirin, other salicylates.\r\n\r\nInfectious diarrhea, high fever, von Willebrand disease, hemorrhage, ulcer or GI bleeding with black or bloody stool, hemophilia.\r\n\r\nIn pediatric patients, chicken pox or influenza (risk of Reye syndrome); changes in behavior with nausea and vomiting may be early sign of Reye syndrome.

Mode of Action

Antimicrobial anti-inflammatory action (bismuth); antisecretory effect (salicylate).

Precaution

May cause black tongue and/or black stool.

Side Effect

>10%\r\nNausea (12%)\r\n\r\n1-10%\r\nDiarrhea (7%),Abdominal pain (7%),Melena (3%),Upper respiratory tract infection (2%),Constipation (2%),Anorexia (2%),Vomiting (2%),Asthenia (2%),Discolored tongue (2%),Headache (2%),Dyspepsia (2%),Dizziness (2%),Stool abnormality (1%),Duodenal ulcer (1%),Sinusitis (1%),Taste perversion (1%),Flatulence (1%),GI hemorrhage (1%),Pain (1%),Insomnia (1%),Anal discomfort (1%),Paresthesia (1%)\r\n\r\nFrequency Not Defined\r\nAnxiety,Confusion,Depression,Tinnitus,Weakness,Gray-black stool,Impaction,Muscle spasm,Neurotoxicity (rare)

Pregnancy Category Note

Pregnancy category: C; D in 3rd trimester\r\n\r\nLactation: Salicylates enter breast milk; use with caution