Indications

Farpem tablet is indicated in the treatment of the following infections:
. Lower respiratory tract infections: acute bronchitis, pneumonia, pulmonary suppuration.
Ear, nose, and throat (ENT) infections: otitis externa, tympanitis, sinusitis.
Genito-urinary infections: pyelonephritis, cystitis, prostatitis, seminal gland inflammation.
. Upper respiratory tract infections: pharyngitis, tonsillitis
Skin and skin structure infections: pustular acne, folliculitis, contagious impetigo, erysipelas, lymphangitis, suppurative nail inflammation, subcutaneous abscess, hidradenitis (sweat gland
inflammation), infective sebaceous cyst, chronic pyoderma, secondary infection of external wounds or surgical wounds.
. Gynecological infections: adnexitis, bartholin gland inflammation.

Pharmacology

Faropenem is a penem class of antimicrobial and has bactericidal activity against a variety of gm-ve, gm+ve and anaerobic bacteria. Faropenem is bactericidal, with a strong affinity for the high
molecular penicillin binding proteins (PBPs) of the cell wall, which is essential for the multiplication of bacilli; it, thus, acts by inhibiting the cell wall synthesis. Faropenem shows broad antibacterial
activity against both aerobic and anaerobic Gram-positive and Gram-negative bacteria. Faropenem is highly stable against various beta lactamases and binds preferentially to the PBPs, 2 and 1A, of
Escherichia coli (E. coli).

Dosage & Administration

Upper respiratory tract infections: 150 mg t.i.d., can be increased to 200 mg t.i.d.
ENT infections: 200 mg t.i.d., can be increased to 300 mg t.i.d.
Lower respiratory tract infections: 200 mg t.i.d., can be increased to 300 mg t.i.d.
Skin and skin structure infections: 150 mg t.i.d., can be increased to 200 mg t.i.d.
Genito-urinary infections: 200 mg t.i.d., can be increased to 300 mg t.i.d.
Gynecological infections: 150 mg t.i.d., can be increased to 200 mg t.i.d.

Interaction

Imipenem and Cilastatin sodium combination: It has been reported that in animal studies (rat), the concentration of Farpem in the blood increases. It is due to the obstruction of metabolic
fermentation by cilastatin.

Furosemide: It has been reported in animal studies (dog), that the kidney toxicity of Farpem increases.

Sodium valproate: It has been reported that due to joint usage with carbapenem drugs (meropenem, panipenem and imipenem-cilastatin sodium) the concentration of valproic acid in the blood
reduces, and there is a recurrence of epileptic fits.

Contraindications

Faropenem is contraindicated in patients with known hypersensitivity to any of the components of this product or to other drugs in the same class, or in patients who have demonstrated anaphylactic
reactions to beta-lactams.

Side Effects

Common side effects of Farpem are Headache, Nausea, Vomiting, Stomach pain and Diarrhea.

Pregnancy & Lactation

Safety regarding therapy during pregnancy has not been established. In pregnant women or expectant mothers, the medicine should be given only if the benefit of the treatment is greater than the
risks involved. Faropenem is excreted in human milk. Therefore, Faropenem should be given to nursing mothers only if the benefits outweigh the risks.