Indications

Biotin is indicated in-

Hair loss
Weak, brittle, splitting or soft nails
Eczema & dermatitis.

Pharmacology

Biotin is an essential vitamin that is also known as vitamin H. It is involved in vital physiological function like fatty acid synthesis, amino acid catabolism and gluconeogenesis. It acts as a cofactor in the enzymatic carboxylation of pyruvate and acetyl-CoA. Biotin influences the growth and differentiation of epidermal cells and is therefore important for the formation and renewal of the skin, hair and nails. It functions as a coenzyme for mitochondrial carboxylases in hair roots and improves the keratin structure. Biotin deficiency may result in hair loss and a variety of systemic symptoms such as dermatitis, and aciduria. Biotin is one of the most prescribed nutritional supplements for any kind of hair loss.

Dosage & Administration

Biotin dose varies depending on disease condition and age group.

In adults: Generally 1-3 tablets per day or as advised by the physician.

In children: biotin deficiency affects between 1 week and 2 years of age and usually exhibits seizures, hypotonia, developmental delay, ataxia, hyperventilation, and coma. In this case, 5-10 tablets daily, crushed and mixed with water or any kind of fruit juice or as advised by the physician.

Recommended dietary allowance:

Infants-

0-6 months: 5 mcg/day
7-12 months: 6 mcg/day

Children-

1-3 years: 8 mcg/day
4-8 years: 12 mcg/day

Males and females-

9-13 years: 20 mcg/day
14-18 years: 25 mcg/day
≥19 years: 30 mcg/day

Pregnancy: 30 mcg/day

Lactation: 35 mcg/day

Interaction

There are indications that anticonvulsant drugs lower the plasma level of biotin. Antibiotic use may decrease the biotin contribution to the body made by the microflora of the large intestine. Excessive consumption of raw egg whites interferes with biotin absorption.

Contraindications

Contraindicated in patients with known hypersensitivity to any of the ingredients.

Side Effects

Well tolerated in the recommended dose. No biotin toxicity has been reported in individuals supplemented with as much as 200 mg orally or 20mg intravenously per day.

Pregnancy & Lactation

Sufficient clinical data is not available to use in pregnant women and lactating mother.

Therapeutic Class

Herbal and Nutraceuticals

Storage Conditions

Store in a cool and dry place, away from light and moisture. Keep out of reach of children.