Introduction

Hepamarin 140 is a flavonoid derived from Silybum marianum, a plant commonly known as milk thistle. Hepamarin 140 exhibits hepatoprotective and regenerative properties and is one of the most widely used natural compounds for the treatment of hepatic diseases worldwide, due to its antioxidant, anti-inflammatory, and antifibrotic activities. Hepamarin 140 also increases hepatic levels of glutathione by raising cysteine availability, while inhibiting its catabolism to taurine that may enhance the antioxidant defense in liver. Hepamarin 140 was found to oppose oxidative stress, and to slow the progression of hepatic fibrosis in alcohol-fed baboons.

Uses of Hepamarin 140

Hepamarin 140 is used for the treatment of Jaundice,chronic inflammatory liver conditions, hepatic cirrhosis ,alcoholic liver damage.

Side effects of Hepamarin 140

Mild digestive upset
Allergic reactions

How to use Hepamarin 140

Take Hepamarin 140 in the dose and duration as advised by your doctor. Take Hepamarin 140 orally with plenty of water. Do not chew, crush or break it.

How Hepamarin 140 work

Different mechanisms of action of Hepamarin 140 are as follow: Increasing the regenerative ability of the liver cells by enhancing the synthesis of DNA and RNA, as Hepamarin 140 has a steroid structure; Altering the structure of the hepatocyte external membrane, that prevents entrance of the xenobiotics into the cell (poisoning with Amanita mushroom is a noteworthy example of such mechanism); Scavenging free radicals and increasing the cellular content of glutathione that leads to the inhibition of lipid peroxidation; Another mechanism of action of Hepamarin 140 is modifying the transporters and receptors of cell membranes such as ABC transporters (P-gp), organic anion uptake transporter peptides (OATP), bile salt export pump, and TNF-α-dependent transporters.

What if you forget to take Hepamarin 140

If you forget to take yourHepamarin 140 , take them as soon as you remember. If it is almost time for your next dose, skip the missed dose and take it at the usual time. Avoid taking two doses at the same time.

Safety Advice

UNSAFE – Alcohol: It is unsafe to consume alcohol with Hepamarin 140.
CONSULT YOUR DOCTOR – Pregnancy: Hepamarin 140 is not recommended for use during pregnancy. Controlled, long-term safety studies are lacking. Please consult your doctor.
CONSULT YOUR DOCTOR – Breastfeeding: No experience is available about the use of Hepamarin 140 .Long-term safety studies are lacking. Please consult your doctor.
SAFE IF PRESCRIBED – Driving: Limited research on the effects of Hepamarin 140 on driving ability.
CAUTION – Kidney: It should be used with caution in patients with kidney disease. Dose adjustment of Hepamarin 140 may be needed. Please consult your doctor.
CAUTION – Liver: It should be used with caution in patients with liver disease. Dose adjustment of Hepamarin 140 may be needed. Please consult your doctor.