Indication

Beriberi and Wernick's encephalopathy, neuritis associated with pregnancy and pellagra.

Administration

Should be taken with food.

Adult Dose

Treatment and prophylaxis of mild chronic thiamine deficiency\r\nAdult: 10-25 mg daily in single or divided doses.\r\n\r\nThiamine deficiency\r\nAdult: 1 tablet (100mg) daily, up to 300 mg daily.\r\n\r\nWernicke-Korsakoff syndrome\r\nAdult: Initially, 100 mg by slow IV Inj over 10 min, then 50-100 mg/day IM or IV until the patient can take oral thiamine.

Child Dose

Thiamine deficiency\r\n10-50 mg/day PO in divided doses\r\n\r\nBeriberi\r\n10-25 mg IV/IM qDay (if crtically ill) or 10-50 mg/dose PO qDay for at least 2 weeks, THEN\r\n\r\n5-10 mg/day PO for 1 month

Contraindication

Hypersensitivity

Mode of Action

Thiamine, a water soluble vitamin, combines with ATP to form thiamine pyrophosphate, an essential coenzyme in carbohydrate metabolism.

Precaution

Parenteral admin. Increased daily requirements in pregnancy and lactation.

Side Effect

IV: Warm sensation, tingling, pruritus, pain, urticaria, weakness, sweating, nausea, restlessness, tightness of the throat, angioedema, respiratory distress, cyanosis, pulmonary oedema, GI bleeding, transient vasodilation and hypotension, vascular collapse. \r\nIM: Tenderness and induration.\r\n\r\nPotentially Fatal: Very rarely, fatal anaphylactic shock.

Interaction

May enhance the effect of neuromuscular blocking agents.