Indications

Goodbac-SB is indicated for the prevention and treatment of:

Diarrhoea associated with antibiotic use
Traveller’s diarrhoea
Recurrent intestinal disease caused by Clostridium difficile
Side effects of treatment for Helicobacter pylori
Symptoms of acute diarrhoea
Diarrhoea in infants
Chronic diarrhoea
Ulcerative colitis and inflammatory bowel disease (IBD)

Composition

Each capsule contains:

Saccharomyces boulardii 250 mg (equivalent to 5 billion CFU) or
Saccharomyces boulardii 500 mg (equivalent to 10 billion CFU)

Pharmacology

Saccharomyces boulardii is a beneficial yeast that survives stomach acid and colonizes the intestinal tract temporarily, protecting the natural gut flora and supporting immunity and digestion.

Mechanisms of action:

Anti-toxin activity: Neutralizes bacterial toxins, including those produced by Clostridium difficile.
Antimicrobial activity: Adheres to pathogens, reducing their attachment to intestinal walls and preventing invasion.
Enzymatic activity: Increases digestive enzyme production (lactase, alpha-glucosidase, alkaline phosphatase) and polyamines that enhance nutrient absorption.
Immune enhancement: Stimulates protective antibodies and strengthens gut immunity.
Anti-inflammatory effect: Reduces pro-inflammatory cytokines.

Dosage & Administration

Antibiotic-associated diarrhoea: 250–500 mg, 2–4 times daily.
Clostridium difficile diarrhoea: 1 g daily for 4 weeks with antibiotic therapy.
Acute diarrhoea: 250 mg twice daily for 5 days.
Crohn’s disease: 250 mg three times daily for up to 8 weeks.
Ulcerative colitis: 250 mg three times daily.
Helicobacter pylori infection: 250–500 mg twice daily with standard treatment.
Irritable bowel syndrome (IBS): 350 mg twice daily.
Traveller’s diarrhoea: 250 mg daily.

Children:

Over 3 months: 250 mg twice daily for 5 days.
Under 3 months: 125 mg twice daily for 5 days.

Interaction

Antifungal medications (e.g., fluconazole, itraconazole, terbinafine) may reduce the effectiveness of Saccharomyces boulardii.

Contraindications

Hypersensitivity to Saccharomyces boulardii or any component of the product.

Side Effects

Generally safe for most adults; may cause mild gas in some individuals.

Pregnancy & Lactation

Safety data in pregnancy and lactation are limited; use only if clearly needed.

Therapeutic Class

Herbal and nutraceutical probiotic supplement