Indications
Mg is indicated for the treatment of the following conditions:
Relieving symptoms of magnesium deficiency
Heart and vascular system: Rapid heartbeat, irregular heartbeat, heart attack, angina pectoris, mild to severe hypertension
Nerve and muscles: Sudden excessive muscle spasms (tetany), muscle cramps, gastrointestinal cramps, increased nerve and muscle excitability, calf cramps, cramps in newborns or small children
Gynecological conditions: Preterm spasms, cervical failure, premature membrane rupture, pregnancy-related spasms (eclampsia/pre-eclampsia), painful menstruation
Orthopedics: Calcification and ossification
Prevention of renal stones: Prevention of recurrence of calcium oxalate kidney stones
Treatment of diabetes and migraine

Pharmacology
Magnesium is a common mineral found in many foods. Magnesium oxide is used to treat or prevent low magnesium levels. It is essential for over 600 cellular reactions and supports bone, brain, heart, and muscle function.
Magnesium reduces convulsions by blocking neuromuscular transmission and decreasing acetylcholine release. It has a depressant effect on the CNS but is considered safe when used properly in eclampsia or pre-eclampsia.
About 24–76% is absorbed in the gastrointestinal tract. Around 20% in serum is protein-bound. It is not metabolized and is mainly excreted through the kidneys.

Dosage & Administration
Recommended dose (above 12 years): 1–2 tablets daily
Missed dose: Take as soon as remembered unless it is near the next dose. Do not double the dose

Kidney failure: Not recommended in severe kidney disease
Liver failure: No sufficient data available

Interaction
Consult doctor if taking:
Muscle relaxants
Certain antibiotics (quinolones, tetracyclines, etc.)
Digoxin
Lithium
Sodium polystyrene sulfonate
Cellulose sodium phosphate
Other magnesium products
Barbiturates, opioids, hypnotics
Nifedipine
Levothyroxine (keep at least 4-hour gap)

Contraindications
Kidney disease patients should consult doctor before use
Use caution in pregnancy and breastfeeding
Not recommended without medical advice in certain conditions

Side Effects
Common: Diarrhea, abdominal cramps
Serious: Rash, itching, dizziness, weakness, fatigue, nausea, vomiting

Pregnancy & Lactation
Consult doctor before use during pregnancy and breastfeeding

Precautions & Warnings
Do not exceed recommended dose
Excess magnesium may cause serious effects
Do not use as antacid for more than 2 weeks or laxative for more than 1 week without doctor advice
Take other medicines 2 hours before or after

Therapeutic Class
Antacids, Electrolyte preparations, Oral electrolyte preparations