Indications Cefim-3 is indicated for the treatment of acute infections caused by susceptible microorganisms, including:

Upper respiratory tract infections (URTI): otitis media and other URTI resistant to common antibiotics or where treatment failure carries significant risk.
Lower respiratory tract infections: bronchitis.
Urinary tract infections: cystitis, pyelonephritis.
Effective against pathogens such as Streptococcus pneumoniae, Streptococcus pyogenes, E. coli, Proteus mirabilis, Klebsiella spp., Haemophilus influenzae (beta-lactamase positive/negative), Moraxella catarrhalis, and Enterobacter spp.

Pharmacology Cefixime is a third-generation oral cephalosporin antibiotic. It is bactericidal, interfering with bacterial cell wall synthesis. It is stable against beta-lactamase enzymes, making it effective against organisms resistant to penicillins and some cephalosporins. Oral absorption is about 40–50%, unaffected by food.

Dosage & Administration

Adults & children >10 years: 200–400 mg daily, as a single dose or in two divided doses.
Children: 8 mg/kg/day, single or divided doses.
- 6 months–1 year: 3.75 ml suspension daily
- 1–4 years: 5 ml daily
- 5–10 years: 10 ml daily
Typhoid (children): 5 mg/kg twice daily for 10–14 days.
Renal impairment:
- CrCl ≥20 ml/min: normal dose.
- CrCl <20 ml/min: do not exceed 200 mg once daily.
- Hemodialysis/peritoneal dialysis: same as CrCl <20 ml/min.

Interactions May increase prothrombin time; caution in patients on anticoagulant therapy.

Contraindications Hypersensitivity to cephalosporins.

Side Effects Generally well tolerated.

Common: Diarrhea, stool changes, abdominal pain, dyspepsia, vomiting, flatulence.
Occasional: Headache, dizziness.
Rare: Rash, pruritus, urticaria, fever, arthralgia, thrombocytopenia, leukopenia, eosinophilia, mild liver/renal function changes, vaginitis.
Serious: Pseudomembranous colitis.

Pregnancy & Lactation No adequate studies in pregnant women. Use only if clearly needed. Unknown if excreted in breast milk; caution advised.

Precautions & Warnings

Use cautiously in patients allergic to penicillins (cross-reactivity possible).
Discontinue if allergic reaction occurs.
Broad-spectrum antibiotics may cause Clostridium difficile-associated diarrhea.
Use in pregnancy/lactation only if essential.