Dermex Spray Active Ingredient: Clobetasol Propionate BP 0.05% Formulation: Topical Spray (60 ml) Manufacturer: Opsonin Pharma Therapeutic Class: Super-high potency topical corticosteroid

Indications Dermex Spray is indicated for adults, elderly, and children over 1 year in the following dermatological conditions:

Scalp psoriasis (excluding widespread plaque psoriasis)
Recalcitrant dermatoses
Lichen planus
Discoid lupus erythematosus
Other dermatoses unresponsive to less potent corticosteroids

Composition Each gram of spray contains Clobetasol Propionate BP 0.5 mg (0.05% w/w).

Pharmacology Clobetasol Propionate is a very potent topical corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictive properties. It acts by inducing phospholipase A₂ inhibitory proteins (lipocortins), which control the biosynthesis of inflammatory mediators such as prostaglandins and leukotrienes by inhibiting the release of arachidonic acid from membrane phospholipids.

Dosage & Administration

Adults, elderly, and children over 1 year: Apply the required quantity once or twice daily to the affected scalp area and rub gently.
Maximum weekly dose should not exceed 50 ml.
Discontinue therapy if no improvement is noted after one week.
For short-term use only. Route of administration: Cutaneous.

Contraindications

Rosacea, acne vulgaris, and perioral dermatitis
Primary cutaneous viral infections (e.g., herpes simplex, chickenpox)
Hypersensitivity to any component of the preparation
Skin infections caused by fungi or bacteria
Dermatoses in children under one year, including diaper rash

Side Effects Prolonged use or application over large areas may cause systemic absorption leading to features of hypercortisolism. Local effects may include skin thinning, striae, telangiectasia, and pigmentation changes. If hypersensitivity occurs, discontinue use immediately.

Pregnancy & Lactation Use only if the potential benefit outweighs possible risks. Caution is advised during lactation, as it is unknown whether the drug is excreted in human milk.

Precautions & Warnings

Avoid long-term continuous therapy, especially in infants and children.
Limit facial use to short courses.
Occlusive dressings should not be used unless directed.
Monitor for signs of adrenal suppression with prolonged use.