Indication

Infected eczema, Skin infection, Corticosteriod-responsive dermatoses, Cuteneous candidiasis with superficial bacterial infection.

Adult Dose

Topical/Cutaneous\r\nCorticosteriod-responsive dermatoses with secondary infection\r\nAdult: As cream/ointment: Apply sparingly to the affected area 2-3 times daily. \r\n\r\nElderly: Use sparingly for short periods of time.

Child Dose

Topical/Cutaneous\r\nCorticosteriod-responsive dermatoses with secondary infection\r\nChild: As cream/ointment: Apply sparingly to the affected area 2-3 times daily. \r\n

Contraindication

Tuberculous, viral lesions of the skin (e.g. herpes simplex and varicella); fungal lesions not susceptible to nystatin, facial rosacea, acne vulgaris or perioral dermatitis. Not to be applied to the external auditory canal in patients with perforated tympanic membranes. Do not use on extensive areas to reduce risk of systemic absorption and neomycin-induced ototoxicity. Not recommended for <1 yr.

Mode of Action

Triamcinolone is a fluorinated corticosteroid with anti-inflammatory, antipruritic and anti-allergic actions. Nystatin, a polyene antifungal antibiotic, binds to ergosterol and interferes with the permeability of cell membrane of susceptible fungi e.g Candida spp. Neomycin is an aminoglycoside, often used topically in the infections against susceptible staphylococci and other organisms. Gramicidin, an antibacterial substance extracted from tyrothricin, is active against many Gram-positive bacteria. Used together, this combination provides a wide coverage against gram-positive, gram-negative bacteria and yeast which are responsible for most of the skin infections.

Precaution

Patients with established hearing loss. Avoid occlusive dressing and prolonged or recurrent use. Avoid contact with eyes or mucous membranes. If there is no clinical improvement after 7 days, discontinue use as the infection may be masked by the steroid. Limit use to 5 days if used on the face or on children ?1 yr. Use with caution and sparingly on inflamed or damaged skin (e.g extensive burns, trophic ulceration). Pregnancy.

Side Effect

Prolonged use may cause sensitivity reactions, impaired wound healing, thinning of skin, striae, telangiectasia, hirsutism, hypothalamic-pituitary-adrenal axis suppression, Cushing's syndrome.