Indication

Eradication of H. pylori infection: One strip twice daily for 7-14 days.\r\n\r\nHepatic impairment: No dosage adjustment needed with hepatic impairment

Adult Dose

Severe hepatic impairment, gastric malignancy. May increase the risk of GI infections due to acid suppressive effects. Pregnancy.\r\n\r\nLactation: Not recommended

Renal Dose

Amoxicillin: Inhibits bacterial cell wall synthesis by binding to one or more penicillin binding proteins that in turn inhibit the final transpeptidation step of peptoglycan synthesis in cell wall biosynthesis. \r\nClarithromycin: Inhibits protein synthesis by binding to 50S ribosomal subunit causing antibacterial activity.\r\n\r\nRabeprazole: Proton pump inhibitor (PPI); binds to H+/K+-exchanging ATPase (proton pump) in gastric parietal cells, blocking acid secretion. \r\n

Precaution

H. pylori infection, Peptic ulcer disease

Side Effect

CrCl< 30 mL/min: Do not use

Pregnancy Category Note

Amoxicillin: Generally classified as Category B. It is considered relatively safe during pregnancy, as animal studies have not shown harm to the fetus.
Clarithromycin: Classified as Category C. Animal studies have shown adverse effects on the fetus. Therefore, it is typically not recommended for use in pregnant women unless there are no alternative treatments.
Rabeprazole Sodium: Generally classified as Category B/C (depending on regional guidelines). While studies in animals haven't shown major risks, there is limited data on its safety in human pregnancy.
Because of the Clarithromycin component, this kit is usually avoided during pregnancy. If a pregnant woman has an H. pylori infection, doctors often wait until after delivery or use an alternative antibiotic combination that does not include Clarithromycin.

Interaction

Hypersensitivity.