Indication

Iron deficiency anemia

Administration

For maximum absorption take on empty stomach, but may take with or after meals to minimize GI irritation

Adult Dose

One capsule daily. In more severe cases, 2 capsules a day may be required

Contraindication

This product is contraindicated in patients with a known hypersensitivity to any of the ingredients.

Mode of Action

Iron: Essential component in the formation of hemoglobin; adequate amounts of iron are necessary for effective erythropoiesis; also serves as a cofactor of several essential enzymes, including cytochromes that are involved in electron transport. Replacement of iron stores found in hemoglobin, myoglobin, and enzymes; works to transport oxygen via hemoglobin.\r\n\r\nFolic acid: Required for nucleoprotein synthesis and the maintenance of normal erythropoiesis; folic acid is converted in the liver and plasma to its metabolically active form, tetrahydrofolic acid, by dihydrofolate reductase; prevents neural tube defects in women of childbearing potential and higher doses required during pregnancy.\r\n

Precaution

Care should be taken in patients who may develop iron overload, such as those with haemochromatosis, haemolytic anemia or red cell aplasia. Iron chelates with tetracycline and absorption may be impaired.\r\n\r\nLactation: Excreted in breast milk

Side Effect

Iron\r\n>10%\r\nConstipation,Diarrhea,Nausea,Epigastric pain,Dark stools,Vomiting\r\n\r\nFrequency Not Defined\r\nHemosiderosis (during long-term administration of large amounts),Urine discoloration,Dental stain by some formulations,Heartburn\r\n\r\nFolic acid\r\nBronchospasm,Erythema,Malaise,Pruritus,Rash,Slight flushing

Interaction

Carbonyl iron: Antacids may decrease the absorption of carbonyl iron.\r\n\r\nFolic acid: Antiepileptics, oral contraceptives, anti-TB drugs, alcohol, aminopterin, methotrexate, pyrimethamine, trimethoprim and sulphonamides may result to decrease in serum folate contrations. Decreases serum phenytoin concentrations.