Indications Uro‑Vaxom is indicated for:

Prevention of recurrent lower urinary tract infections (UTIs).
Co‑medication in the treatment of acute urinary tract infections.

Composition Each capsule contains:

Lyophilized bacterial lysate of Escherichia coli — 6 mg (lysates of 18 pathogenic strains isolated from patients with recurrent UTIs). Excipients: starch, magnesium stearate, propyl gallate (E310), sodium glutamate, mannitol, yellow iron oxide (E172), red iron oxide (E172), titanium dioxide (E171), gelatin.

Pharmacology Uro‑Vaxom is a biological immunostimulant that strengthens the immune system’s natural defenses, helping prevent recurrent UTIs, especially cystitis. It can also be used alongside antibiotics during acute infections.

After oral administration, Uro‑Vaxom activates innate immune cells (phagocytes and antigen‑presenting cells) through pattern recognition receptors in Peyer’s patches (gut‑associated lymphoid tissue). These cells mature and migrate to the urinary tract, providing localized protection.

Mechanism of Action:

Innate Immunity: Increases cytokine production, adhesion molecules, and phagocytosis for rapid defense.
Adaptive Immunity: Stimulates lymphocyte activation and IgA/IgG antibody production, offering humoral protection in the urinary tract.

By reinforcing immune defenses and reducing bladder inflammation, Uro‑Vaxom lowers recurrence rates of UTIs and provides a long‑term immunotherapeutic alternative to antibiotics.

Dosage & Administration

Adults and children ≥4 years:
- Preventive treatment: 1 capsule daily (morning, on an empty stomach) for 3 consecutive months.
- Acute infection: 1 capsule daily (morning, on an empty stomach) as co‑medication with antibiotics for at least 10 consecutive days or until symptoms resolve.
Children <4 years: Safety and efficacy not established. Do not alter dosage without medical advice.

Interaction No known drug interactions. Uro‑Vaxom is not contraindicated with immunosuppressants, though they may reduce its efficacy.

Contraindications Known hypersensitivity to any component of Uro‑Vaxom.

Side Effects

Common (≤1 in 10): Diarrhea, nausea, headache, stomach discomfort.
Uncommon (≤1 in 100): Allergic reactions, abdominal pain, rash, itching, fever.
Very rare (≤1 in 10,000): Swelling of mouth, ankles, feet, or fingers; hair loss.

Pregnancy & Lactation

Pregnancy: Preferably avoid use, especially during the first trimester.
Breastfeeding: Use only after consulting a physician.