Indication

Nutritional Supplement in Osteoporosis, Calcium deficiency, Rickets, Hypocalcaemia, Calcium supplement, Osteomalacia

Adult Dose

Dosage should be individualized based on the demands in age, sex and various physiological (pregnancy & lactation) & disease conditions. In general the dosage is-\r\nAdults: 1 effervescent tablet daily\r\n

Child Dose

Dosage should be individualized based on the demands in age, sex and various physiological (pregnancy & lactation) & disease conditions. In general the dosage is-\r\nChildren above 7 years: 1 effervescent tablet daily\r\nChildren 3-7 years: Half effervescent tablet daily

Contraindication

Absolute contraindications are hypercalcaemia resulting from myeloma, bone metastases or other malignant bone disease, sarcoidosis; primary hyperparathyroidism and Vitamin-D overdosage. It is also contraindicated in severe renal failure and hypersensitivity to any of the tablet ingredients.

Mode of Action

Calcium carbonate/vitamin D3 prevents or treats negative Ca balance. It also helps facilitate nerve and muscle performance as well as normal cardiac function. Bone mineral component; cofoactor in enzymatic reactions, essential for neurotransmission, muscle contraction, and many signal transduction pathways.\r\n\r\nVitamins and minerals are essential for normal metabolic functions including hematopoiesis. Vitamin D3 is a fat-soluble sterol. It is necessary for the regulation and regulation of calcium and phosphate homoeostasis and bone mineralisation. Vitamin D is also essential for healthy bones as it aids in Calcium absorption from the GI tract. \r\n\r\nVitamin C is necessary for collagen formation and tissue repair; plays a role in oxidation/reduction reactions as well as other metabolic pathways including synthesis of catecholamines, carnitine, and steroids; also plays a role in conversion of folic acid to folinic acid.\r\n

Precaution

Patients with mild to moderate renal failure or mild hypercalciuria should be supervised carefully. Periodic checks of plasma Calcium levels and urinary Calcium excretion should be made in patients with mild to moderate renal failure or mild hypercalciuria. In patients with a history of renal stones urinary Calcium excretion should be measured to exclude hypercalciuria. With long-term treatment it is advisable to monitor serum and urinary Calcium levels and kidney function, and reduce or stop treatment temporarily if urinary Calcium exceeds 7.5 mmol/24 hours. Allowances should be made for Calcium and Vitamin-D supplements from other sources.\r\n\r\nLactation: Calcium enters human milk; use with caution

Side Effect

Calcium \r\nAnorexia, Constipation, Flatulence, Nausea, Vomiting, Hypercalcemia, Hypophosphatemia, Xerostomia, Acid rebound, Milk-alkali syndrome\r\n\r\nVitamin D\r\nHypercalcemia, Muscle/bone pain, Metallic taste, Headache, Nausea, Vomiting, Dry mouth, Constipation, Arrhythmias\r\n

Interaction

Vitamin D3 and Vitamin C work together to maximize calcium absorption and bone density, but this combination can reduce the effectiveness of antibiotics or thyroid medications if taken at the same time.