Description : Apit Oral Suspension contains Megestrol Acetate, a synthetic progestin with antineoplastic and appetite‑stimulating properties. It is indicated for the palliative treatment of advanced breast and endometrial cancer, especially in recurrent, inoperable, or metastatic cases. Additionally, Apit is prescribed to manage anorexia, cachexia, or significant weight loss in patients with AIDS or cancer.

Key Benefits:

Supports appetite stimulation and weight gain
Effective in hormone‑dependent cancer management
Convenient oral suspension for easy administration
Manufactured under strict quality standards by Drug International Ltd.

Pharmacology: Megestrol Acetate binds to progesterone receptors, reducing estrogen activity and exerting antineoplastic effects. It also stimulates appetite and promotes weight gain. Peak plasma concentration occurs within 2–3 hours, with a half‑life of 33–38 hours. Excretion is mainly via urine and feces.

Dosage & Administration:

Recommended adult dose: 800 mg/day (≈ 20 ml/day)
Treatment should continue for at least 2 months to evaluate effectiveness
Administer orally with water, with or without food

Side Effects: Weight gain, nausea, vomiting, abdominal discomfort, headache, fatigue, edema, libido changes, and cholesterol increase. Rare but serious risks include thrombosis, pulmonary embolism, stroke, liver inflammation, and adrenal suppression.

Precautions: Use with caution in patients with thromboembolic disorders, liver disease, or fluid retention. Should be taken only under medical supervision.