Indications: Bilxen is indicated for the symptomatic treatment of:

Allergic rhinoconjunctivitis (seasonal and perennial)
Urticaria It is also used to relieve symptoms of hay fever such as sneezing, itchy or blocked nose, and red, watery eyes.

Pharmacology: Bilastine is a potent, selective, non‑sedating, long‑acting H₁‑antihistamine with high affinity for H₁ receptors (three times higher than cetirizine and five times higher than fexofenadine). Even at high concentrations, Bilastine shows no affinity for other receptor types (muscarinic, serotonergic, dopaminergic, adrenergic, or other histamine subtypes H₂, H₃, H₄). It has an excellent safety profile and favorable pharmacokinetics. Bilastine does not require metabolic activation and is excreted unchanged — approximately 64.35% via feces and 20.3% via urine.

Dosage & Administration:

Adults and adolescents (≥12 years): 20 mg tablet once daily for symptomatic relief of allergic rhinitis, urticaria, and rhinoconjunctivitis. Maximum daily dose: 20 mg. If a dose is missed, take the next scheduled dose; do not double doses. Tablets should be swallowed with water on an empty stomach for optimal absorption.
Children (6–11 years): 10 mg mouth‑dissolving tablet once daily. Place on the tongue to dissolve or disperse in a teaspoon of water before swallowing.
Children (2–5 years): 4 ml syrup once daily.

Interactions: Concomitant use with ketoconazole, erythromycin, cyclosporine, or diltiazem increases Bilastine concentration but does not affect safety. Alcohol intake with 20 mg Bilastine shows similar psychomotor performance to placebo. Co‑administration with lorazepam does not potentiate CNS depression.

Contraindications: Hypersensitivity to Bilastine or any excipients in the formulation.

Side Effects: Commonly reported side effects include headache, dizziness, somnolence, and fatigue — occurring at similar frequency to placebo.

Pregnancy & Lactation: Limited data in pregnant women. Animal studies show no harmful effects on reproduction. As a precaution, avoid use during pregnancy. Excretion in human milk is unknown; weigh benefits of breastfeeding against maternal therapy needs.

Precautions & Warnings: Treatment with Bilastine 20 mg does not impair driving performance, though rare drowsiness may occur. No dose adjustment is required in elderly or renally impaired patients. Bilastine is minimally metabolized and primarily excreted renally; hepatic impairment is not expected to affect elimination.

Use in Special Populations: Safety and efficacy in children under 2 years have not been established; limited clinical experience in ages 2–5 years — use not recommended in this group.