Indications

Adults (≥10 years):
- Gastroesophageal reflux disease (GERD)
  - Non-erosive reflux disease (NERD): heartburn, regurgitation
  - Maintenance treatment of NERD
  - Reflux esophagitis (erosive esophagitis)
  - Maintenance treatment of reflux esophagitis
- Healing of NSAID-associated gastric ulcers
- Reduction of risk of NSAID-associated gastric ulcers
- Zollinger–Ellison syndrome
- H. pylori eradication (in combination therapy)
Pediatrics (12–17 years):
- GERD
  - Non-erosive reflux disease (NERD): heartburn, regurgitation
  - Reflux esophagitis (erosive esophagitis)

Composition

20 mg tablet: Esomeprazole Magnesium Trihydrate USP equivalent to Esomeprazole 20 mg.
40 mg tablet: Esomeprazole Magnesium Trihydrate USP equivalent to Esomeprazole 40 mg.
20 mg capsule: Esomeprazole Magnesium Trihydrate USP equivalent to Esomeprazole 20 mg.
40 mg capsule: Esomeprazole Magnesium Trihydrate USP equivalent to Esomeprazole 40 mg.

Description (MUPS Technology)

Pharmacology

Esomeprazole is a proton pump inhibitor (PPI).
Blocks gastric acid secretion by inhibiting H+/K+ ATPase (proton pump) in gastric parietal cells.
Effective for short-term treatment of gastric and duodenal ulcers.
Also used for prevention and treatment of NSAID-associated gastric ulcers.

Dosage

Adults (≥10 years):
- NERD: 20 mg once daily for 2–4 weeks
- Maintenance of NERD: 20 mg once daily
- Reflux esophagitis: 20–40 mg once daily for 4–8 weeks
- Maintenance of reflux esophagitis: 20 mg once daily
- Healing of NSAID-associated ulcers: 20 mg once daily for 4–8 weeks
- Prevention of NSAID-associated ulcers: 20 mg once daily
- Zollinger–Ellison syndrome: 40 mg twice daily
- H. pylori eradication:
  - 20 mg twice daily for 7 days (with amoxicillin 1000 mg + clarithromycin 500 mg)
  - Or 40 mg once daily for 10 days (with antibiotics)
Pediatrics (12–17 years):
- NERD: 20 mg once daily for 2–4 weeks
- Reflux esophagitis: 20–40 mg once daily for 4–8 weeks

Administration

Taken orally with or without food.
Swallow whole with liquid; do not chew or crush.
If needed, disperse tablet in half a glass of non-carbonated water, stir until disintegrated, drink immediately or within 30 minutes.
Rinse glass with water and drink to ensure full dose.
Pellets must not be chewed or crushed.