Indications Cefixime is a third-generation oral cephalosporin antibiotic used for the treatment of susceptible bacterial infections, including:

Upper Respiratory Tract Infections (URTI)
- Otitis media (middle ear infection)
- Other URTIs caused by susceptible bacteria
Lower Respiratory Tract Infections
- Bronchitis
Urinary Tract Infections (UTI)
- Cystitis
- Cystourethritis
- Pyelonephritis

Effective against organisms such as:

Streptococcus pneumoniae
Streptococcus pyogenes
Escherichia coli
Proteus mirabilis
Klebsiella species
Haemophilus influenzae
Moraxella catarrhalis
Enterobacter species

Pharmacology Cefixime is a third-generation semisynthetic cephalosporin antibiotic. It works by inhibiting bacterial cell wall synthesis, resulting in bacterial death. It is highly stable against many beta-lactamase enzymes and has an oral absorption rate of approximately 40% to 50%.

Dosage and Administration

Adults and Children Over 10 Years

200 to 400 mg daily
Given as a single dose or in two divided doses
Usual treatment duration: 7 days (up to 14 days if needed)

Children

Recommended dose: 8 mg/kg/day
Given as a single dose or in two divided doses

General daily suspension dose:

6 months to 1 year: 3.75 mL
1 to 4 years: 5 mL
5 to 10 years: 10 mL

Typhoid Fever

5 mg/kg twice daily for 10 to 14 days

Children Over 50 kg or Above 10 Years

Adult dosage: 200 to 400 mg daily

Elderly

Same dose as adults unless severe renal impairment is present.

Renal Impairment

Creatinine clearance ≥20 mL/min: Normal dosage
Creatinine clearance <20 mL/min: Maximum 200 mg once daily