Indications

Revocitis indicated in-
The control of serum phosphorus levels in adult patients with chronie kidney disease on dialysis.
The treatment of iron deficiency anemia in adult patients with chronie kidney disease not on dialysis.

Feup

Pharmacology

Ferrie iron binds dietary phosphate in the Gl tract and precipitates as fernie phosphate. This compound is insoluble and is excreted in the stool. By binding phosphate in the GI tract and decmeasing absorption,
terrie iron lowers the phosphate concentration in the serum. Ferre iron is reduced from the ferrie to the ferrous form by ferrie reductase in the Gl tract. After transport through the enterocytes into the blood,
codidized ferric iron cireulates bound to the plasma protein transferrin, and can be incorporated into hemoglobin.

Dosage & Administration

Hyperphospatemia in Chronic Kidney Disease on Dialysis:
. Starting dose is 2 tablets orally 3 times per day with meals
. Adjust dose by 1to 2 tablets as needed to maintain serum phosphorus at target levels, up to a maximum of 12 tablets daily. Dose can be titrated at 1-week or longer intervals.
Iron Deficiency Anemia in Chronic Kidney Disease not on Dialysis
Starting dose is 1tablet orally 3 times por day with meals
Adjust dose as needed to achieve and maintain hemoglobin goal, up to a maximum of 12 tablets daily or as directed by the physician.
Use in Children & Adoleseents: The safety and efficacy of Ferrie Citrate have not been established in Children & Adolescents.

Interaction

Oral drugs such as Doxycycline & Ciprofloxacin have to be separated from Revocit.

Contraindications

Ferric Citrate is contraindicated in patients with iron overload syndrome (Hemochromatosis).

Side Effects

Most common adverse reactions are discolored feces, diarrhoca, constipation, nausea, vomiting, cough, abdominal pain and hyperkalemia.

Pregnancy & Lactation

There are no available data on Ferric Citrate use in pregnant women & Lactating mother.

Precautions & Warnings

Iron absorption from Phoscon may lead to excessive elevations in iron stores. May increase in serum ferritin and transferrin saturation (TSAT] levels. Patients may require a reduction in dose or discontinuation of
intravenous iron.

Accidental overdose of iron-containing products is a leading cause of fatal polsoning in children under 6 years of age. Keep Revocit out of reach of children. In case of accidental overdose, call a doctor or poison
control center in hospital immediately.

Overdose Effects

No data are avallable regarding overdose of Revocit in patients. In patients with Chronic Kidney Disease, the maximum dose studied was 2,520 mg ferrie iron per day.

Therapeutic Class

Oral Iron preparations

Storage Conditions

Store below 30C, away from light and in a dry place. Keep out of the reach of children.