Indications

Vitamin D3 deficiency can occur in people whose exposure to sunlight is limited and in those whose diet is deficient in vitamin D3.
. D-Vine is essential for the effective calcium and phosphate absorption required for healthy bones and teeth, preventing rickets, osteomalacia and osteoporosis.
. D-Vine is also essential to prevent pre-eclampsia during pregnancy and breast feeding as it is an essential nutrient for a growing infant.
D-Vine has vital role on immunity boost up.

Meningococcal Conjugate
A, C. W-135 & Y Vaccine

Pharmacology

The active form of Vitamin D3, Calcitriol, exerts its effect by binding to the Vitamin D receptors (VDRs) which are widely distributed through many body tissues.Vitamin D3 has a half life of about 50 days
as it is fat soluble.Vitamin D3 is absorbed in the small intestine and bound to specific a-globulins and transported to the liver where it is metabolised to 25-hydroxy Vitamin D3 (Calcidiol). A second
hydroxylation to 1,25-dihydroxy Vitamin D3 (Calcitriol) occurs in the kidney. This metabolite is responsible for the vitamin's ability to increase the absorption of calcium. Non-metabolised Vitamin D3 is
stored in tissues such as fat and muscle.Vitamin D3 is eliminated via faeces and urine.

Dosage & Administration

For capsule: Adults:
. Treatment of Vitamin D3 deficiency: 40000 IU once weekly for 7 weeks. Doses for maintenance therapy is 1400-2000 IU/day. To confirm the target level of 25 hydroxyvitamin D, measurement of it
should be determined 3-4 months after initiating the maintenance therapy
Prevention of Vitamin D3 deficiency: 20000 IU every 4 weeks. Higher doses may be required in certain situations.
. Addition to specific therapy for osteoporosis: 20000 IU once a month.
For capsule: Children (12-18 years):
. Treatment of Vitamin D3 deficiency: 20000 IU once every 2 weeks for 6 weeks.
. Prevention of Vitamin D3 deficiency: 20000 IU every 6 weeks.
For film-coated tablet: 1000 IU (1-2 tablets) daily, or as directed by physician. Take the medicine with food or within 1 hour after a meal.

For oroflash or chewable tablets: 1000 IU to 2000 IU daily, or as directed by physician. Take the medicine with food or within 1 hour after a meal. Place the tablet in mouth swallow after chewing.

For Oral Solution:
. Up to one year: 400 IU once a day or as directed by the physician.
. 1 year to 18 years: 600 IU once a day or as directed by the physician.
Injection: For treatment
Rickets: 1 ampoule every 2 weeks for one month then 1 ampoule for every 4 months
. Osteoporosis: 1 ampoule every 2 weeks for 3 months
. Osteomalacia: 1 ampoule every 2 weeks for 3 months
. Tetany caused by hypocalcaemia: 1 ampoule for every 4 months which may be increased to 2 ampoules
. Menopause: 1 ampoule for every 6 months
. Vitamin 03 deficiency: 1 ampoule can be repeated 1 to 6 months later
Injection: For prevention-
. Pregnancy: 1/2 ampoule at 6th or 7th months
. During breastfeeding: 1/2 ampoule for every 6 months
. Children up to 5 years: 1 ampoule for every 6 months
. Adolescent: 1 ampoule for every 6 months
. Elderly Dosages: 1/2 ampoule for every 3 months.
Direction of use of Injection-
For oral use-
. Step-1: Place the thumb on ampoule and break the upper narrow part of the ampoule.
. Step-2: Pour out the solution of the ampoule in a spoon.