Indications

Sergel is indicated:
. To relieve from chronic heartburn symptoms and other symptoms associated with GERD
. For the healing of erosive esophagitis
. For maintenance of healing of erosive esophagitis
. In combination with amoxicillin and clarithromycin for eradication of Helicobacter pylori infection in patients with duodenal ulcer disease.
Zollinger-Ellison Syndrome
. Acid related Dyspepsia
. Duodenal & Gastric ulcer

Pharmacology

Esomeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase in the gastric parietal cell. Esomeprazole (S-isomer of omeprazole) is the first
single optical isomer of proton pump inhibitor, provides better acid control than racemic proton pump inhibitors.

Absorption: Esomeprazole capsules contain an enteric-coated pellet formulation of esomeprazole magnesium. After oral administration peak plasma levels (Cmax) occur at approximately 1.5 hours
(Tmax). The Cmax increases proportionally when the dose is increased, and there is a three-fold increase in the area under the plasma ... Read more

CEP

Realty MUPS

ENSURES FASTER & EFFECTIVE CONTROL
of Hyperacidity Related Disorders

ujChanical

Progut MUPS

Manulactured with
The Unique & World Class
Cushioning Agent
Fujicalin

Dosage

Oral dosage form-
. Healing of Erosive Esophagitis: 20 mg or 40 mg Once Daily for 4-8 Weeks. The majority of patients are healed within 4 to 8 weeks. For patients who don't heal after 4-8 weeks, an additional 4-8
weeks of treatment may be considered. Maintenance of Healing of Erosive
. Esophagitis: 20 mg Once Daily (Clinical studies did not extend 6 months).
. Symptomatic GERD: 20 mg Once Daily for 4 Weeks. If symptoms do not resolve completely after 4 weeks, an additional 4 weeks of treatment may be considered.
. Helicobacter Pylori eradication: Triple Therapy to reduce the risk of Duodenal Ulcer recurrence-Esomeprazole 40 mg Once Daily for 10 days, Amoxicillin 1000 mg Twice Daily for 10 days,
Clarithromycin 500 mg Twice Daily for 10 days
Zollinger-Ellison Syndrome: The dose is 20-80 mg once daily. The dosage should be adjusted individually and treatment continued as long as clinically indicated.
. Acid-related Dyspepsia: 20-40 mg once daily for 2-4 weeks according to the response.
. Duodenal ulcer: 20 mg once daily for 2-4 weeks. Gastric ulcer: 20-40 mg once daily for 4-8 weeks.

IV Injection or IV infusion:

GERD with Erosive Esophagitis-
Adult Patients (≥18 years):
. 20 mg or 40 mg once daily
IV Injection: >3 Minutes, IV Ir

ion: 10-30 minutes