Introduction

Gout is an inflammatory disease triggered by deposition of urate crystals secondary to longstanding hyperuricemia, and its management implies both the treatment of flares and management of hyperuricemia. Dotinor 1 is a selective urate reabsorption inhibitor (SURI), potently inhibits urate transporter 1 in the apical surface of renal proximal tubular cells, and has been approved for the treatment of gout and hyperuricemia.

Uses of Dotinor 1

For the treatment of gout and hyperuricemia.

Side effects of Dotinor 1

The most common side effects are gouty arthritis, limb discomfort (1% to less than 5%). (Loose stools, increased y-GTP, arthralgia, kidney stones, nephrocalcinosis, increased urinary y2 macroglobulin, increased blood creatinine, increased urine albumin/creatinine ratio, positive urine albumin) has been reported in less than 1% patients.

How to use Dotinor 1

_NAME_ administered orally once daily. The maintenance dose is usually 2 mg once a day and maximum dose should be 4 mg once a day.

How Dotinor 1 works

Dotinurad is a URAT1-selective urate reabsorption inhibitor that selectively inhibits URAT1 and inhibits urate reabsorption, thereby increasing urinary urate excretion and lowering serum urate levels. In addition, since it has weak inhibitory effects on ABCG2, OAT1 and OAT3 other than URAT143,44, it is expected to effectively lower serum uric acid levels without affecting uric acid secretion via these transporters. Thus, Dotinurad is a selective urate reabsorption inhibitor (SURI) that inhibits the reabsorption pathway mediated by URAT1 without inhibiting the uric acid secretion pathway mediated by ABCG2, OAT1 and OAT3 because of its high URAT1 selectivity.

What if you forget to take Dotinor 1?

Take the missed dose as soon as possible when you remember. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Never take two doses at once. Do not stop taking this medicine without your doctor's advice.

Safety Advice

CAUTION – Alcohol: Caution is advised when consuming alcohol with Dotinor 1 Please consult your doctor.
CONSULT YOUR DOCTOR – Pregnancy: During pregnancy, Dotinor 1 should only be treated if the therapeutic benefits are judged to outweigh the risks.
CONSULT YOUR DOCTOR – Breastfeeding: This drug is excreted in breast milk. Consult your doctor before breastfeeding.
CAUTION – Driving: It is not known whether Dotinor 1 alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
CONSULT YOUR DOCTOR – Kidney: Consider treatment with other agents. Since this drug acts in the renal proximal tubule, its efficacy may be reduced depending on the degree of renal dysfunction. In particular, administration of this drug should be avoided in patients with oliguria or anuria, as its efficacy cannot be expected.
CAUTION – Liver: Careful follow-up should be performed. Serious liver damage has been observed with other uricosuric agents.