Indication

Megaloblastic anaemia, Peripheral neuropathies

Administration

May be taken with or without food.

Adult Dose

Oral\r\nPeripheral neuropathies\r\nAdult: 1500 mcg/day in 3 divided doses.\r\n\r\nParenteral\r\nPeripheral neuropathies\r\nAdult: 500 mcg daily IM/IV 3 times/wk.\r\n\r\nMegaloblastic anaemia caused by vitamin B12 deficiency\r\nAdult: 500 mcg daily IM/IV 3 times/wk. \r\nMaintenance dose: After about 2 mth of therapy, reduce dose to single admin of 500 mcg every 1-3 mth.

Contraindication

Hypersensitivity to any component of this product.

Mode of Action

Mecobalamin is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes.

Precaution

The medicine should not be used for months if there is no response at all after its use for a certain period of time.

Side Effect

Oral: Anorexia, nausea, vomiting and diarrhoea. Parenteral: Rash, headache, hot sensation, diaphoresis and pain/induration at IM inj site.\r\n\r\nPotentially Fatal: Anaphylactoid reactions (parenteral).

Interaction

Decreased GI tract absorption with neomycin, aminosalicylic acid, H2-blockers and colchicine. Reduced serum concentrations with oral contraceptives. Reduced effects in anaemia with parenteral chloramphenicol.