Indications

Magnide is indicated for the treatment of following condition:
. Relieving the symptoms of magnesium deficiency
. Heart and vascular system: Heartbeat acceleration, heartbeat irregularities, heart attack, angina pectoris, mild severe hypertension
. Nerve and muscles: Sudden and excess spasm in muscle (tetani), spasm formation in muscle, stomach-intestine cramps, increased stimulability of muscle and nerves, calf cramps, cases with
cramps and stress in new-born or small children
. Gynecological diseases, related to birth and baby: Preterm spasms, cervical failure, early membrane rupture, spasm in pregnancy (eclampsia/pre-eclampsia, tocolysis necessary to use
betamimetic), menstrual period with pain
. Orthopedics: Calcification and ossifications
. Prevention of renal calculus formation: Prevention of renal calculus formation (prevention of repetition of calcium oxalate urolithiasis)
. Treatment of diabetic and migraine (a type of headache)

Pharmacology

Magnesium is one of the most common minerals on earth and is present in many foods. Magnesium oxide is a mineral supplement used to treat or prevent low levels of magnesium in the blood. It's
essential for human health and is used over 600 cellular reactions throughout the body. In fact, every cell and organ need this mineral to function properly. It contributes to bone health, as well as
proper brain, heart and muscle function.

Magnesium prevents or controls convulsions by blocking neuromuscular transmission and decreasing the amount of acetylcholine liberated at the end plate by the motor nerve impulse. Magnesium is
said to have a depressant effect on the central nervous system (CNS), but it does not adversely affect the woman, fetus or neonate when used as directed in eclampsia or pre-eclampsia.

Approximately 24-76% of ingested magnesium is absorbed in the gastrointestinal tract, primarily via passive par cellular absorption in the small intestine. 20% of the magnesium found in human serum
is protein bound. Approximately 60-70% of this fraction is bound to albumin while the remainder is bound to globulin proteins. Magnesium has the ability to bind to 3751 human proteins. Magnesium
does not appear to be metabolized. The majority of magnesium is excreted renally.

Dosage & Administration

Recommended daily dose for patient over 12 years of age is 1-2 tablet. If a dose of Magnesium Oxide is missed take it as soon as remember, unless it's almost time for the next dose. In that case, skip the
missed dose and continue on regular medication schedule. Do not double up on doses to make up for a missed dose.

Kidney failure: Do not take this medication in the patient with severe kidney failure.
Liver failure: There is no data about usage in the patients with liver failure.

Interaction

Other drugs may affect the treatment with this medicine. Before taking Magnide, talk to doctor if taking-
. Muscle relaxant drugs (non-depolarize neuromuscular blockers)
. Some antibiotic (amino quinolones, nitrofurantoin, penisilamine, tetracyclines, fluoroquinolones)
. Digoxin (heart failure treatment)
Lithium (change of emotion and control of depression state)
. Sodium polystyrene sulfonate (provides elimination of potassium)
. Cellulose sodium phosphate (used to prevent kidney stones)
. Other medicines containing magnesium (including magnesium enemas)
. Barbiturate (drugs used for the treatment of sleeplessness), opioids (substances acting as morphine), hypnotics (somnific drugs)
. Nifedipine (drugs used in hypertension or heart problems)
. The absorption of levothyroxine containing drugs which are used in the treatment of thyroid diseases, is impaired when used concomitantly, therefore at least 4 hours interval is required between
the uses of these two drugs.

Contraindications

. Do not take this drug without first talking to your doctor if you have kidney disease.
. Before taking this drug, tell your doctor if you have any other medical conditions, allergies, or if you take other medicines or other herbal/health supplements. This drug may not be recommended
in some situations.
It is not known whether this drug will harm an unborn baby.