Introduction

Uses of Rimactazid 450

Tuberculosis (TB)

Side effects of Rimactazid 450

Dark colored urine
Rash
Vomiting
Jaundice
Fever
Increased liver enzymes
Nausea
Peripheral neuropathy (tingling and numbness of feet and hand)

How to use Rimactazid 450

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Rimactazid 450 is to be taken empty stomach. \nAvoid Rimactazid 450 with tyramine-rich food such as cheese, smoked fish, meats and some types of beer.

How Rimactazid 450 works

Rimactazid 450 is a combination of two antibiotics: Rifampicin and Isoniazid, which treats tuberculosis (TB). Rifampicin works by inactivating a bacterial enzyme (RNA-polymerase) which is required by TB bacteria to make essential proteins and to reproduce. Isoniazid prevents these bacteria from forming their own protective covering. Together, they kill the bacteria and eradicate the infection.

Quick Tips

You have been prescribed Rimactazid 450 for the treatment of tuberculosis.
Finish the full course of the medication, even if you feel better. Stopping it early may make the infection come back.
Take it on an empty stomach, preferably at the same time everyday.
It may discolour your urine, sweat, saliva and tears a reddish-orange colour. This is normal and not harmful.
Your doctor may check your liver function before starting treatment and regularly thereafter. Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain.
Avoid drinking alcohol while taking Rimactazid 450 as this may increase the risk of side effects on the liver.
Use an alternative or additional contraceptive method (such as condoms or a diaphragm) to prevent pregnancy while you are taking Rimactazid 450 as it may make hormonal contraceptives such as the pill less effective.
Do not take indigestion remedies (antacids) within at least two hours of taking Rimactazid 450.

Safety Advice

UNSAFE – Alcohol: Consuming alcohol while taking Rimactazid 450 may cause symptoms such as flushing, increased heart beat, nausea, thirst, chest pain and low blood pressure (Disulfiram reaction).
CONSULT YOUR DOCTOR – Pregnancy: Rimactazid 450 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED – Breastfeeding: Rimactazid 450 is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
UNSAFE – Driving: Rimactazid 450 may cause side effects which could affect your ability to drive.\nRimactazid 450 can cause fits, mental health problems and optic neuritis (inflammation of the optic nerve that may cause loss of vision.) This may affect your driving ability.
CAUTION – Kidney: Rimactazid 450 should be used with caution in patients with kidney disease. Dose adjustment of Rimactazid 450 may be needed. Please consult your doctor.
CAUTION – Liver: Rimactazid 450 should be used with caution in patients with liver disease. Dose adjustment of Rimactazid 450 may be needed. Please consult your doctor.\nUse of Rimactazid 450 is not recommended in patients with severe liver disease.