Indications

Pidonex is an immunostimulant that boost up immunity system in immunodeficiency conditions that predispose an individual to frequent infections, specially respiratory tract infections. It is indicated for
recurrent upper and lower respiratory tract infections in children and adults, acute respiratory tract inections, asthma, chronie obstructive pulmonary disorders, chronie bronchitis, rhinitis, sinusitis, poumonia
and immunological disorders.

Pharmacology

n general, Pidotimod reinforces and stimulates both the immunological mechanisms involved in humoral immunity and those of cellular immunity mediated by T lymphocytes. At the same time, it stimulates and
ncreases the migration of the macrophage which is an essential and primordiall point in the cellular immune response where it serves the purpose of obtaining an adequate phagocytosis and elimination of the
infectious germ. Pidotimod has an effective and efficient prophylactie and protective action against infections by Gram positive and Gram-negative germs that is not due to an intrinsic antimicrobial property of
pidotimod but rather to its immunostimulant effect.

Pidotimod is rapidly absorbed following oral administration. For the Pidotimod tablet, the mean peak plasma concentration is achieved 1.5 hours after administration in adults. oral bioavailability was 42-44. The
Administration with food does not affect the axtent of absorption of Pidotimod but results in a delay in the absorption of the drug and a reduction in its bioavallability of up to 50%. So, it is recommended to
administer Pidotimod two hours before or two hours after food. It is widely distributed throughout the body. Pidotimod is almost completely absorbed when administered orally. It undergoes little metabolism in
the liver. No known metabolites. Its binding to plasma proteins is very poor, a fact that represents an advantage, because it does not interfere with other medications. It has a half-life of approximately 4 hours. It
s eliminated mainly in the urine and little in the feces.

Dosage & Administration

Acute Phase:
. Dose in adults: Take 2 tablets of 400 mg or 1tablet of 800 mg, twice a day, two hours before or two hours after food and for 15 days.
Dose in the elderly and children: Take 1 tablet of 400 mg, twice a day, two hours before or two hours ater food and for 15 days.
Prophylactic Phasc:
. Dose in adults: Take 2 tablets of 400 mg or 1tablet of 800 mg, once a day, two hours before or two hours after food and for 60 days.
Elderly and children: Take 1 tablet of 400 mg, 1time a day, two hours before or two hours after food and for 60 days.
Missed Dose: Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Interaction

Pidonex does not intertere with the use of antibioties nor does it modity the side effects caused by them. Pidonex can interact with drugs that block or stimulate lymphocyte activity, such as thymostimulin. It
can also interfere with those mechanisms that are somchow connected to IgE, such as hyper IgE syndromes. The intake of Pidonex with food results in a delay in the absorption of the drug and a reduction in its
bioavailability of up to 50%

Contraindications

Should not be administered simultancously with immunosuppressive treatment or in patients with known hypersensitivity to Pidotimod.

Side Effects

Iit is generally well tolerated, but diarrhea may rarely ocour in some patients. At high doses and based on experience, sedation, ataxia, dyspnea, and cyanosis may occur.

Pregnancy & Lactation

There are no adequate and well-controllied studies in pregnant women. It should not recommend during the first trimester of pregnancy. During pregnancy, Pidotimod should only be used taking into account the
risk benefit factor and under medical supervision. It is not excreted by breast milk. Consult your doctor before taking it.

Precautions & Warnings

Inform the doctor if Patients are allergie to Pidonex or other medicines. Before taking this medicine, let the doctor know it he has kidney disease or diabetes. Doctor should also know about all other medications
re taking, as many of these may make this medicine less effective or change how it works. And also, inform the doctor if Patients are pregnant or breastfeeding. Pidonex to be taken with caution, especially it
patients are children below 12. In this case, doctor may adjust your dose depending on patient's age. Consumption of alcohol with Pidonex is not advisable as it may cause unpleasant side affects. Do not smoke-
t can make patients symptoms worse. does not cause any adverse effect of carcinogenesis. Nor have mutagenie, teratogenic and fertility alterations been found.

Use in Special Populations

Pediatric Use: Pidonex Tablet is recommended not to be taken by children less than 3 years. It is recommended to consult a doctor before giving it to children so as to decide the required dosage of the medicine
on the basis of body mass, age and condition of infection.

Geriatrie Use: Pidonex Tablet should be used with caution in elderly patients especially the ones suffering from kidney diseases. Consult your doctor before using Pidonex Tablet

Overdose Effects
There are no clinical daa on overdose when administered at doses higher than those recommended. However, the acute toxicity of Pidonex is low: In these cases, slight sedation, ataxia, dyspnea, and cyanosis