Indications

Primacap capsule is indicated in:
. Premenstrual syndrome symptoms (PMS)
Benign breast disease & cyclical mastalgia
Lactation
Atopic, allergic & neurodermatitis
. Psoriasis
Hypertension
Rheumatoid arthritis
Thrombosis
Atopic eczema
Dietary aid
. Promotes healthy skin, nourishes brittle nails & hair.

Description

Primacap Primrose is a plant native to North America. It is obtained from the seeds of plant. It has been used medicinally in Europe since the 16th century. Clinical studies have focused on its use in the
treating problems associated with essential fatty acid (EFA) deficiency including premenstrual syndrome, atopic eczema, inflammation and diabetic peripheral neuropathy. Primacap (EPO) is relatively
high in essential fatty acids (EFAs), particularly gamma-linolenic acid (GLA,7-10%).

Pharmacology

Improves EFA composition of plasma, erythrocytes, platelet lipids and atocopherol levels in non-diabetic persons and Type 1 diabetic patients; increase total fat and EFA contents of mother's milk;
affects fatty acid composition of serum lipids and adipose tissue in men with low dihoma-gamma-linolenic acid (DGLA) levels; helps maintain normal cellular structures and in the precursor of DGLA,
which is the parent of the 1-series prostanoids and as a precursor of arachidonic acid, the parent of the 2-series prostanoids.

Evening Primrose Oil supplies gamma-linolenic acid (GLA). The bioactivity of EPO is due primarily to its GLA contents. By supplying GLA, it bypasses the rate-limiting step in the metabolism of LA. After
ingestion of EPO, GLA is rapidly absorbed and then converts directly to DGLA and other prostaglandin precurosors. It also acts on the prostanoids pathway.

Dosage & Administration

Atopic & Allergic Dermatitis:
. Adult dosage: 1 capsule 2 times daily.
. Children dosage: 1 capsule 1/2 times daily.
Benign Breast disease & Mastalgia: 1 capsule 2/3 times daily with or after meal.
Premenstrual Syndrome (PMS): 1 Capsule 2 times daily at morning & night with or after meal.
Rheumatoid arthritis: 1 Capsule daily Or as directed by the registered physician.

Contraindications

Previously it was not recommended for patients diagnosed with schizophrenia. However, a recently published analysis of clinical trials involving polyunsaturated fatty acids in the treatment of
schizophrenia did not indicate a clear therapeutic or adverse effect of evening primrose oil supplements on schizophrenic patients.

Side Effects

Side effects are rare at recommended dosages. Overdose may cause loose stool and abdominal pain.

Pregnancy & Lactation

Linolenic acid, GLA and DGLA are important components of human breast milk, so it is responsible to assure that evening primrose oil may be taken while nursing. According to World Health
Organization (WHO), pregnant or lactating women should get 5% of their total daily caloric intake from EFAs.