Description (English)

Brand Name: Loxodol
Generic Name: Lornoxicam
Strength: 4 mg per tablet
Manufacturer: Navana Pharmaceuticals Ltd.
Therapeutic Class: Non-steroidal Anti-inflammatory Drug (NSAID)
Indications:
- Short-term relief of acute mild to moderate pain
- Symptomatic relief of pain and inflammation in osteoarthritis
- Symptomatic relief of pain and inflammation in rheumatoid arthritis
Pharmacology: Lornoxicam inhibits prostaglandin synthesis (via cyclooxygenase enzyme inhibition), reducing inflammation and pain sensitivity.
Dosage & Administration:
- Acute Pain: 4–8 mg daily, divided into 2–3 doses (max 16 mg/day).
- Osteoarthritis/Rheumatoid Arthritis: Initial dose 8–12 mg daily in 2–3 divided doses; maintenance not exceeding 16 mg/day.
- Elderly: No special adjustment, but gastrointestinal side effects are less tolerated.
- Renal/Hepatic Impairment: Maximum 12 mg/day in divided doses.
- Children/Adolescents (<18 years): Not recommended.
Side Effects: Nausea, vomiting, diarrhea, constipation, abdominal pain, peptic ulcers, GI bleeding, dizziness, headache.
Precautions:
- Avoid in patients with peptic ulcer, severe renal/hepatic impairment, bleeding disorders, asthma, or systemic lupus erythematosus.
- Contraindicated in third trimester of pregnancy and not recommended during breastfeeding.
Drug Interactions:
- Increased bleeding risk with warfarin.
- May reduce kidney function with cyclosporin.
- Can enhance toxicity of lithium, methotrexate, digoxin.
- Reduced effect of diuretics, ACE inhibitors, and ARBs in heart failure patients.