Indications

Caripa is indicated for -
. Thrombocytopenia (low platelet count) associated with Dengue.
. Thrombocytopenia (low platelet count) induced by chemotherapy.
Caripa also-
. Increases the taste of food
Aids in digestion
- Eliminates constipation
Reduces inflammation of the stomach and colon
. Keeps the liver clean
. Boost immunity
. Removes acne
. Ensures healthy and beautiful skin
. Relieves menstrual pain.

Pharmacology

Carica papaya, belongs to the plant family Caricaceae, is an economically important fruit crop worldwide. Many scientific works have been carried out to evaluate the benefit of different parts of papaya
plant including fruits, seeds, leaves, rind, shoots, roots or latex. The leaf is considered non-toxic as its lethal dose is >15 g/kg body weight.

Preclinical studies in mice demonstrated encouraging the activity of Carica papaya powder in increasing platelet count. Recently in vitro study showed that Carica papaya leaves extract exhibited
significant inhibition of hemolysis probably due to its membrane stabilizing potency.

Dosage & Administration

Adults: The recommended dose of 250 mg 1-2 capsules daily 2-3 times a day for 5-12 days.

For children more than 1 year and less than 5 years: 1 teaspoonful (5ml) three times a day for 5 days

For children more than 5 years and less than 18 years: 2 teaspoonful (10ml) three times a day for 5 days

Above 18 years & above: 3 teaspoonful (15 ml) three times a day for 5 days or as directed by a physician

Interaction

It has been found to increase the bioavailability of amiodarone and therefore the dose should be adjusted accordingly when co-administered with Caripa. In vitro study demonstrated potentiating the
action of various antibiotics like penicillin G, ampicillin, amoxyclav, cephalothin, polymyxin B, rifampicin, amikacin, nalidixic acid, gentamycin, chloramphenicol, ofloxacin when co-administered with C.
papaya. The extract of C. papaya with antimicrobial agents possesses synergistic properties which act against pathogenic organisms.

Contraindications

Hypersensitivity, Pregnancy. In males with prostate dysfunction, such as BPH or prostate cancer, Carica
papaya should be avoided as it increases the iron absorption. Excess iron may increase oxidative stress, especially in the aging male. Iron overload may increase the risk of developing prostate cancer.

Side Effects

No health hazards or side effects are known in conjunction with the proper administration of designated therapeutic dosages.

Pregnancy & Lactation

Not recommended in pregnancy and lactation.