Indications

This gel is indicated for the following scar treatment:
. hypertrophic and keloid scars
. scar that occurs after surgery
. scar that occurs after amputation, burns and trauma
. scar due to traumatic tendon contracture

Pharmacology

Extract of Allium cepa: It is derived from the membrane of Allium cepa (onion membrane). It shows antiphlogistic efects through inhibition of infammatory mediators' secretion and anti-allergenic
efect. Extract of Allium cepa inhibits growth of fbroblast of diferent origin, particularly kelloidal fbroblasts. It has also bactericidal efect. While these properties stimulate primary wound healing, it
prevents non-physiological scar formation.

Heparin: In case of local application, it shows inhibitory efect on fbroblast proliferation. While heparin increases tissue hydration, it reduces irritation resulted from induration and infammation.

Allantoin: Allantoin stimulates cellular proliferation. It also supports the development of healthy cells. Allantoin is convenient substance for the treatment of scar through its properties of stimulating
epithelization and providing elastic surface formation.

Clinical studies:
. Evaluation of the use of Extract of Allium cepa, Heparin & Allantoin gel for the prevention of scar formation: Total 1,268 patients were evaluated and after 2 to 3 months of treatment with
Extract of Allium cepa, Heparin & Allantoin gel, a reduction of 31.5% in mean scar width and 47.8% reduction of mean scar height at the end of the observation period.
. Assessment of the use of Extract of Allium cepa, Allantoin, and Heparin in the early treatment of C-section scars: A total of 61 females, aged ≥18 years, who had given birth by C-section
were evaluated. After six weeks of treatment, the gel showed signifcant improvement of the color, stifness and irregularity of C-section scars.

Dosage & Administration

This gel should be applied 3-4 times a day to the affected area and massaged gently in order to achieve better penetration. Continue with a circular motion until the gel is completely absorbed.
Treatment may take several weeks or months depending on the size of existing scars and contracture.

This gel is very safe and its tolerability has been proven in numerous clinical studies. Small children and even babies can be treated safely.

Interaction

There is no known and reported drug interaction.

Contraindications

This gel should not be used in patients with known hypersensitivity to any of its ingredients.

Side Effects

This gel is generally well tolerated even in long-term use. In rare cases, some local irritations are reported such as slight erythema and itching. These side effects do not require discontinuation of the
treatment.

Pregnancy & Lactation

There are no studies conducted during pregnancy and lactation periods. Therefore it should be used with caution.

Precautions & Warnings

During treatment of fresh scars with Antiscar, excess cold, UV lights and abrupt massage should be avoided. Avoid contact with eyes, the inside of the nose or mouth and other mucous membranes.