Indication

Allergic conditions

Administration

Should be taken with food. Take during or shortly after meals.

Adult Dose

Oral\r\nAllergic conditions\r\nAdult: 100-300 mg/day.\r\n

Child Dose

Oral\r\nAllergic conditions\r\nChild: <2 yr: 50-100 mg/day; \r\n2-5 yr: 50-150 mg/day; \r\n5-10 yr: 100-200 mg/day; \r\n>10 yr: 100-300 mg/day.

Contraindication

Premature infants and neonates. Acute asthmatic attack.

Mode of Action

Mebhydrolin is an ethylenediamine derivative antihistamine with antimuscarinic and sedative properties.

Precaution

Closed-angle glaucoma; urinary retention, prostatic hyperplasia or pyloroduodenal obstruction; epilepsy. Elderly. Pregnancy. May impair ability to drive or operate machinery.

Side Effect

CNS depression; paradoxical stimulation (high doses, children or elderly); headache, psychomotor impairment; dry mouth, thickened respiratory tract secretions, blurred vision; urinary difficulty or retention, constipation, increased gastric reflux; nausea, vomiting, diarrhoea, epigastric pain. Rarely, blood disorders. Convulsions, sweating, myalgia, paraesthesias, extrapyramidal effects, tremor, sleep disturbances, depression, confusion, tinnitus, hypotension, hair loss.\r\n\r\nPotentially Fatal: Anaphylaxis.

Interaction

Enhanced sedation with alcohol or other CNS depressants. Additive antimuscarinic effects with MAOIs, atropine, TCAs. May mask warning symptoms caused by ototoxic agents e.g. aminoglycoside antibiotics.