Indication

Skin and nail fungal infections, Tinea pedis, Tinea cruris, Tinea corporis, Candidiasis, Pityriasis versicolor

Adult Dose

Topical/Cutaneous Skin and nail fungal infections: Adult: Apply 2 or 3 times daily. \r\nOnychomycosis: for 6 months. Tinea pedis & Dermatomycoses: for 4 weeks.

Child Dose

Tinea Corporis/Tinea Pedis\r\nApply to affected area q12hr for 4 weeks\r\n\r\nTinea Cruris\r\n>2 years: Apply to affected area q12hr for 2 weeks\r\n\r\nCandidiasis\r\nGently massage sufficient clotrimazole into affected and surrounding area q12hr; reconsider diagnosis if no improvement after 4 weeks\r\n\r\nTinea Versicolor\r\nGently massage sufficient clotrimazole into affected and surrounding area q12hr; reconsider diagnosis if no improvement after 4 weeks

Contraindication

Hypersensitivity.

Mode of Action

Clotrimazole is a broad-spectrum antifungal which binds to phospholipids in the cell membrane altering cell wall permeability causing a loss in essential intracellular elements.

Precaution

Avoid contact with eyes upon topical application. Childn <3 yrs. Pregnancy, lactation.If local intolerance develops, consider withdrawal of the medicine and institution of appropriate therapy. \r\n\r\nLactation: Excretion in milk unknown; use with caution

Side Effect

Elevated serum AST (SGOT) concentrations (15%)\r\nTopical: Erythema, stinging, irritation; hypersensitivity reactions; contact dermatitis. \r\nEdema, Pruritus, Burning, Stinging, Peeling, Urticaria, Skin fissures

Pregnancy Category Note

Pregnancy\r\nSmall amounts of imidazoles may be absorbed systemically following topical and vaginal administration\r\n\r\nLactation\r\nExcretion in milk unknown; use with caution

Interaction

Antagonism with polyene antibiotics.