Indications

This is indicated in-
Joint pain
Cartilage formation
. Supports the structure and function of the joint

Pharmacology

Collagen type II (native) is a protein that is part of the cartilage, bone & other types of connective tissues. Type Il collagen, like all collagen, is made up of three chains of amino acids: glycine, proline and
hydroxyproline, which is known as a triple helix. Undenatured type II chicken collagen is a nutritional supplement derived from chicken sternum cartilage using a patented, low temperature, non-enzymatie
manufacturing process that preserves the natural triple helix molecular confguration and its biological activities. Boswellie acids are the major constituents of the gum derived from the plant Boswellia serrata
Roxb. The gum resin comprises of B-boswellie acids as the main triterpenie acid along with 1-keto-B-boswellie acids and their acetates.

Type Il collagen acts as an antigen, causing an autoimmune response that stimulates the production of anti-inflammatory cell-signaling proteins called cytokines. Undenatured collagen type Il has unique
mechanism of action. Undenatured collagen type II molecules contain active binding sites called epitopes which trigger the process of oral tolerization. Through oral tolerization process, active apitopes of
undenatured collagen type Il interact with Peyer's patches [lymphoid tissue) of small intestine to release collagen-specifie regulatory T-cells. Collagen- specifie ragulatory T-cells then migrate to joint areas and
prevent release of T-cells.

Preventing the release of T-cells prevent the secretion of collagenase enzymes by macrophages responsible for breakdown of collagen in joint cartilage. It also slows the production of inflammatory cytokines
resulting in reduction of inflammation, halting the erosion of joint cartilage and promote cartilage rebuilding. Undenatured collagen type II supports joint funetion, mobility and fiexibility and also improves knee
extension by up to 10% for better range of motion. It also relieves joint pain due to strenuous exercise. Chicken collagen also contains the chondroitin & glucosamine which help in rebuilding cartilage. The
resinous part of Boswellia serrata possesses monoterpenes, diterpenes, triterpenes, tatracyclie triterpenie acids and four major pentacydlie triterpenie acids Le. B-boswellie acid, acetyl-B-boswellic acid, 11-kato-
B-boswallic acid & acetyl-11-keto-B-boswellic acid, responsible for inhibition of pro-inflammatory enzymes.

Dosage & Administration

1 capsule daily or as advised by the registered physician.

Contraindications

Contraindicated in patient with known hypersensivity to chicken or agg.

Side Effects

Well tolerated in the recommended dose. Constipation and headache may have occurred at high dose.

Pregnancy & Lactation

Scientific information is limited on the use of Undenatured collagen type II & Boswellia Serrata Extract during pregnancy or lactation.

Therapeutic Class

Drugs for Osteoarthritis, Herbal and Nutraceuticals, Specific mineral & vitamin combined preparations

Storage Conditions

Store away from light, in a dry and cool place. Store below 30"C. Keep all medicines out of the reach of children. For sale and use only under the preseription of a registered physician.