Furoclav Tablets (Cefuroxime + Clavulanic Acid)

Indications: Furoclav is indicated for the treatment of infections caused by sensitive bacteria, including:

Pharyngitis/Tonsillitis (Streptococcus pyogenes)
Acute bacterial otitis media (Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, Streptococcus pyogenes)
Acute bacterial maxillary sinusitis (Streptococcus pneumoniae, Haemophilus influenzae)
Lower respiratory tract infections including pneumonia (Streptococcus pneumoniae, Haemophilus influenzae, Klebsiella spp., Staphylococcus aureus, Streptococcus pyogenes, E. coli)
Acute bacterial exacerbation of chronic bronchitis and secondary bacterial infections of acute bronchitis
Uncomplicated skin and skin-structure infections (Staphylococcus aureus, Streptococcus pyogenes)
Uncomplicated urinary tract infections (E. coli, Klebsiella pneumoniae)
Bone and joint infections (Staphylococcus aureus)
Uncomplicated gonorrhoea (Neisseria gonorrhoeae)
Early Lyme disease (Borrelia burgdorferi)
Septicemia (Staphylococcus aureus, Streptococcus pneumoniae, E. coli, Haemophilus influenzae, Klebsiella spp.)
Meningitis (Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis, Staphylococcus aureus)
Switch therapy (injectable to oral)

Pharmacology: Cefuroxime is a bactericidal second-generation cephalosporin antibiotic, effective against a wide range of Gram-positive and Gram-negative organisms, including many beta-lactamase producing strains. It works by inhibiting bacterial cell wall synthesis. Clavulanic acid is a naturally derived beta-lactamase inhibitor that binds irreversibly to beta-lactamase enzymes, protecting cefuroxime from degradation and extending its spectrum against resistant bacteria.

Dosage & Administration:

Adolescents and adults (13+ years):
- Pharyngitis/Tonsillitis: 250 mg twice daily for 5–10 days
- Sinusitis: 250 mg twice daily for 10 days
- Chronic bronchitis exacerbation: 250–500 mg twice daily for 10 days
- Acute bronchitis (secondary infections): 250–500 mg twice daily for 5–10 days
- Skin infections: 250–500 mg twice daily for 10 days
- Urinary tract infections: 250 mg twice daily for 7–10 days
- Gonorrhoea: 1000 mg single dose
- Pneumonia: 250–500 mg twice daily for 5–10 days
- MDR Typhoid: 500 mg twice daily for 10–14 days
- Lyme disease: 500 mg twice daily for 20 days
Paediatric patients (3 months–12 years):
- Pharyngitis/Tonsillitis: 20 mg/kg/day in two doses for 5–10 days
- Otitis media: 30 mg/kg/day in two doses for 10 days
- Sinusitis: 30 mg/kg/day in two doses for 10 days
- Impetigo: 30 mg/kg/day in two doses for 10 days

Cefuroxime-Clavulanic Acid tablets may be taken with or without food.

Interactions: Probenecid increases cefuroxime serum concentration. Drugs reducing gastric acidity may lower cefuroxime bioavailability.

Side Effects: Generally well tolerated. Possible side effects: nausea, vomiting, diarrhea, abdominal pain. Rare (<0.2%): renal dysfunction, anaphylaxis, angioedema, rash, pruritus, serum sickness-like urticaria.

Pregnancy & Lactation: Avoid in the first trimester if possible. Safe in later pregnancy for urinary and other infections. Excreted in breast milk in small amounts; monitor infant for sensitization.

Precautions & Warnings: Use with caution in patients on potent diuretics or with history of colitis.

Storage Conditions: Store below 30°C in a cool, dry place, away from light and moisture. Keep out of reach of children.