Indications: Rolip (Rosuvastatin) is indicated for:

Primary hyperlipidemia and mixed dyslipidemia (as an adjunct to diet) to reduce elevated total cholesterol, LDL‑C, ApoB, non‑HDL‑C, and triglycerides, and to increase HDL‑C.
Hypertriglyceridemia (as an adjunct to diet).
Primary dysbetalipoproteinemia (Type III hyperlipoproteinemia) as an adjunct to diet.

Pharmacology: Rosuvastatin is a selective, competitive inhibitor of HMG‑CoA reductase, the rate‑limiting enzyme in cholesterol biosynthesis.

It increases hepatic LDL receptors, enhancing LDL uptake and catabolism.
It inhibits hepatic VLDL synthesis, reducing circulating VLDL and LDL particles.

Dosage & Administration:

Pediatric (10–17 years, heterozygous familial hypercholesterolemia): 5–20 mg/day; max 20 mg/day.
Very high cholesterol / high MI or stroke risk: 40 mg once daily.
Homozygous familial hypercholesterolemia: Start at 20 mg once daily.
Asian patients: Initiate with 5 mg once daily.
With cyclosporine: Limit to 5 mg once daily.
With lopinavir/ritonavir or atazanavir/ritonavir: Limit to 10 mg once daily.
With gemfibrozil: Avoid; if necessary, limit to 10 mg once daily.
Severe renal impairment (CrCl <30 mL/min/1.73 m²): Start at 5 mg once daily; max 10 mg/day.

Interactions:

Contraindications:

Side Effects: Generally well tolerated. Common adverse events: headache, myalgia, constipation, asthenia, abdominal pain, nausea.

Pregnancy & Lactation: Contraindicated. Discontinue immediately if pregnancy occurs. Not recommended during breastfeeding.

Precautions & Warnings:

Caution in patients predisposed to myopathy (elderly, hypothyroidism, renal impairment).
Risk of myopathy increases with fibrates, niacin, gemfibrozil, cyclosporine, lopinavir/ritonavir, atazanavir/ritonavir.
Discontinue if creatine kinase markedly elevated or myopathy suspected.
Monitor liver enzymes before therapy, at 12 weeks, and periodically thereafter.

Overdose Effects: No specific treatment. Provide symptomatic and supportive care. Hemodialysis does not significantly enhance clearance.

Therapeutic Class: Statins (Other anti‑anginal & anti‑ischemic drugs).