Indications: Denvar is indicated for the treatment of infections caused by susceptible microorganisms, including:

Upper Respiratory Tract Infections (URTI): Otitis media, pharyngitis, tonsillitis, and other URTI resistant to common antibiotics.
Lower Respiratory Tract Infections: Bronchitis, pneumonia.
Urinary Tract Infections (UTI): Cystitis, pyelonephritis.

Pharmacology: Cefixime is a third-generation semi-synthetic cephalosporin antibiotic for oral use. It is bactericidal, interfering with bacterial cell wall synthesis. Highly stable against beta-lactamase enzymes, making it effective against resistant strains.

Dosage & Administration:

Adults & Children >10 years: 200–400 mg daily (single or divided dose).
Children (6 months–10 years): 8 mg/kg/day (single or divided dose).
Typhoid fever: 5 mg/kg twice daily for 10–14 days.
Renal impairment: Adjust dose if creatinine clearance <20 ml/min.

Side Effects: Generally well tolerated. Possible adverse effects: diarrhea, nausea, abdominal pain, headache, dizziness, rash, pruritus. Rare: pseudomembranous colitis, thrombocytopenia, transient liver/renal function changes.

Precautions & Warnings:

Use with caution in patients allergic to penicillins/cephalosporins.
Discontinue if hypersensitivity occurs.
Broad-spectrum antibiotic use may cause Clostridium difficile–associated diarrhea.
Use in pregnancy/lactation only if essential.

Storage: Store below 30°C, protected from light and moisture. Keep out of reach of children.