Introduction Coport M 500 is a fixed-dose combination of empagliflozin (a sodium-glucose cotransporter 2 [SGLT2] inhibitor) and metformin hydrochloride (a biguanide). It is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus when treatment with both agents is appropriate. Additionally, Coport M 500 is indicated to reduce the risk of cardiovascular death in adults with type 2 diabetes mellitus and established cardiovascular disease. However, its effectiveness in reducing cardiovascular mortality has not been fully established.

Uses

Treatment of adults with type 2 diabetes mellitus.

Side Effects

Nausea
Vomiting
Diarrhea
Headaches
Dizziness
Fatigue
Abdominal pain
Increased urination
Weight loss

How to Use Take Coport M 500 exactly as prescribed by your doctor. Swallow whole with food. Do not chew, crush, or break the tablet.

Mechanism of Action

Empagliflozin blocks SGLT2, preventing glucose reabsorption and promoting urinary glucose excretion.
Metformin decreases hepatic glucose production, improves insulin sensitivity, and lowers blood sugar levels.

Missed Dose If you miss a dose, take it as soon as you remember. If it is close to the next scheduled dose, skip the missed dose. Do not double the dose.

Safety Advice

Alcohol: Unsafe – may increase risk of lactic acidosis.
Pregnancy: Unsafe – contraindicated.
Breastfeeding: Unsafe – contraindicated.
Driving: Use caution – may cause dizziness or hypotension.
Kidney: Consult doctor – contraindicated in severe renal impairment.
Liver: Use caution – not suitable for severe hepatic impairment.