Indications Cefim‑3 DS is an orally active cephalosporin antibiotic with marked in‑vitro bactericidal activity against a wide range of Gram‑positive and Gram‑negative organisms. It is indicated for the treatment of infections caused by susceptible microorganisms, including:

Upper respiratory tract infections (URTI): pharyngitis, tonsillitis, otitis media, and other URTIs resistant to common antibiotics or where treatment failure carries significant risk.
Lower respiratory tract infections: bronchitis.
Urinary tract infections (UTI): cystitis, urethritis, pyelonephritis. Clinical efficacy has been demonstrated against Streptococcus pneumoniae, Streptococcus pyogenes, Escherichia coli, Proteus mirabilis, Klebsiella spp., Haemophilus influenzae (β‑lactamase positive and negative), Moraxella catarrhalis (β‑lactamase positive and negative), and Enterobacter spp. Cefim‑3 DS is highly stable in the presence of β‑lactamase enzymes.

Pharmacology Cefixime is a third‑generation semi‑synthetic cephalosporin antibiotic for oral use. It is bactericidal against a broad spectrum of Gram‑positive and Gram‑negative bacteria by interfering with bacterial cell‑wall synthesis. It remains stable in the presence of β‑lactamase enzymes, making it effective against organisms resistant to penicillins and some cephalosporins. Absorption is about 40–50%, unaffected by food.

Dosage & Administration Absorption is not significantly affected by food. Usual treatment duration is 7 days, extendable up to 14 days if required.

Adults & children > 10 years: 200–400 mg daily, as a single dose or divided doses.
Elderly: same as adults; adjust dose in severe renal impairment.
Children: 8 mg/kg/day as a single or divided dose.
- Up to 1 year: 3.75 ml daily
- 1–4 years: 5 ml daily
- 5–10 years: 10 ml daily
Typhoid: 5 mg/kg twice daily for 10–14 days.
Children > 50 kg or > 10 years: use adult dose.
Infants < 6 months: safety not established.
Renal impairment: if creatinine clearance < 20 ml/min, do not exceed 200 mg once daily.

Interaction As with other cephalosporins, increased prothrombin time may occur; caution in patients on anticoagulant therapy.

Contraindications Hypersensitivity to cephalosporin antibiotics.

Side Effects Generally well tolerated. Most adverse effects are mild and self‑limiting.

Gastrointestinal: diarrhea, nausea, abdominal pain, dyspepsia, vomiting, flatulence; pseudomembranous colitis reported.
CNS: headache, dizziness.
Allergic: rash, pruritus, urticaria, drug fever, arthralgia.
Hematologic: thrombocytopenia, leukopenia, eosinophilia (rare, reversible).
Miscellaneous: genital itching, vaginitis, transient liver or renal function changes.

Pregnancy & Lactation No adequate controlled studies in pregnant women; use only if clearly needed. Unknown if excreted in human milk—exercise caution in nursing mothers.