Indications

Jointec Pro is indicated for the treatment of osteoarthritis of knee, hip, spine, hand, and other locations as a dietary supplement. It is also beneficial in rheumatoid arthritis, sport injuries, migraine, different skin
problems (e.g, psoriasis], vascular complications (e. g., atherosclerosis), kidney stones, and inffammatory bowel disease (e.g., ulcerative colitis, leaky gut syndrome).

Pharmacology

Glucosamine is a natural amino-sugar, produced by the body and found in certain foods. It is the most fundamental building block required for biosynthesis of glycosaminoglycans [GAGs] like Hyaluronic Acid,
Keratan Sulfate, and Chondroitin Sulfate. GAGs binds with protein and form proteoglycans, the essential building block of articular cartilage. When cartilage in a joint deteriorates, Osteoarthritis develops. It also
helps to form ligaments, tendon, nails, and various other connective tissues.When we take artifcially synthesized Glucosamine Sulfate supplement, it inereases Glucosamine level in the body, thus facilitates
production and repair of cartilage. Glucosamine also activates chondrocytes in the cartilage which help produce BAGs and proteoglycans.

Chondroitin Sulfate is a glycosaminoglycan (acid muco polysaccharide) found in connective tissue, especially in the articular cartilage of all mammals. Chondroitin Sulfate supplement acts similarly as
Glucosamine Sulfate, since it also provide substrate for proteoglycans. Chondroitin also proteets existing healthy cartilage from premature decline by preventing the MMP (Matri metalloproteinase) enzyme that
breakdown the proteoglycans.

Combining Glucosamine with Chondroitin Sulfate shows synergistic effect. Data supports that this combination has been shown to be very much effective in severe cases of Osteoarthritis that treats both sign
and symptoms of Osteoarthritis & modifies disease progression. It prevents Osteoarthritis in case of normal adults. In Osteoarthritic pain it is as effective as NSAIDs with significantly better tolerability and dlinical
compliance. It is also helpful during the repair phase of musculo-skeletal sot tissue injuries such as tendon or ligament strains

Dosage & Administration

250/200 mg tablet: 1 to 2 tablets, three times daily. Dose may be adjusted according to the response of the drug and body weight. Doses can be tapered after 60 days as per requirement of the individual and for
cost convenience. Typical dosage recommendation, based on body weight is as follows-
. Under 54 Kg: 1000 mg Glucosamine Sulfate & 800 mg Chondroitin Sulfate per day
54 Kg to 91 Kg: 1500 mg Glucosamine Sulfate & 1200 mg Chondroitin Sulfate per day
Over 91 Kg: 2000 mg Glucosamine Sulfate & 1600 mg Chondroitin Sulfate per day.
750/600 mg tablet: 1 tablet two times daily or as directed by the physician.

Interaction

There have been no reports of significant drug interactions of Glucosamine and Chondroltin with Antibiotics/ Antidepressants/ Antihypertensives/ Nitrates/ Antiarrythmics/Ardolytics/ Hypoglycemic agents/
Antisecretives/ Antlasthmatics. Chondroitin may enhance the blood thinning effects of anticoagulants like Warfarin, Heparin.

Contraindications

There are no known contraindications for Glucosamine and Chondroitin. But proven hypersensitivity [e. g. allergie to shellfish or sulfur] to Glucosamine and Chondroltin is a contraindication.

Side Effects

Safety studies with Glucosamine Sulfate & Chondroitin Sulfate show no demonstrable side effects. Rarely occurring side effects (such as, mild & reversible intestinal flatulence) are almost like placebo.

Pregnancy & Lactation

Women who are pregnant or who could become pregnant should not supplement with Glucosamine Sulfae or Chondroitin Sulfate. Glucosamine and Chondroitin has not been studied enough to determine their
effects on a developing fetus. No studies have evaluated the use of Glucosamine and Chondroitin during pregnancy or lactation. It should be taken with caution and medical advice during pregnancy and
lactation.

Precautions & Warnings

Patients with Diabetes Mellitus are advised to monitor blood glucose levels regularty when taking Glucosamine. No special stucies were formed in patients with renal or hepatic insutticiency. The toxicological and
pharmacokinetic profile of Glucosamine and Chondroitin does not indicate limitations for these patients. However, administration to patients with severe hepatic or renal insutficiency should be under appropriate
medical supervision. Children should not be supplemented with Glucosamine and Chondroitin.

Therapeutic Class

Stimulation of Cartilage formation

Storage Conditions
Store in a cool and dry place, protected from light.