Indication

Allergic and inflammatory conditions of the eye

Adult Dose

Sterile Ophthalmic Suspension:\r\nBacterial infection: The dosage depends on the severity of the disease. The application of 1 drop 5 times daily into the conjunctival sac of the affected eye is recommended. \r\nIn severe cases the dosage can be increased up to 1 drop per hour for 1 to 2 days.\r\n\r\nOcular postoperative infection: 1 drop 4 times daily into the conjunctival sac for 1 week. Then a reduced application frequency is recommended for the remaining part of the treatment.\r\n\r\nSterile Eye Ointment:\r\nBacterial infection: Apply 3-4 times daily into the affected eye.\r\nOcular postoperative infection: To support the therapy with Ophthalmic Suspension during the night apply ointment before retiring.

Contraindication

Hypersensitivity to any of the components. Injuries and ulceration of the cornea. Viral infections (e.g. Herpes simplex, Vaccinia) or mycosis.\r\nEye tuberculosis. Glaucoma.

Mode of Action

Fluorometholone suppresses the migration of polymorphonuclear leukocytes and reversal of increased capillary permeability thus decreasing inflammation.\r\n\r\nGentamicin is an aminoglycoside that binds to 30s and 50s ribosomal subunits of susceptible bacteria disrupting protein synthesis, thus rendering the bacterial cell membrane defective.

Precaution

Steroids can mask, activate or aggravate ocular infections.\r\n\r\nLong term treatment with steroid may enhance thinning of cornea and sclera and rarely perforation of the cornea has been reported.\r\n\r\nIn case no improvement is observed after 7-8 days of treatment, other therapeutical means should be considered.\r\n\r\nPatients experiencing blurred vision after application of the product, particularly the ointment, should refrain from driving vehicles or operating machinery.\r\n\r\nContact lenses should be removed before each application.

Side Effect

A transient burning sensation may occur after instillation. Rare: Hypersensitivity reactions including eczema of the eyelid and puncture keratitis. Prolonged use of topical steroids may delay wound healing, increase of IOP, develop cataract and cause thinning of cornea & sclera.