Indications

Relief of discomfort associated with acute, painful musculoskeletal conditions in adults.
Sedation and reduction of anxiety in patients with severe pain.
Adjunct in physical therapy for musculoskeletal injuries.

Pharmacology Carisoprodol is an indirect agonist of GABA-A receptors, enhancing CNS chloride channel conductance.

Dosage & Administration

Adults (≥18 years): 250–350 mg three times daily and at bedtime.
Maximum recommended duration: 2–3 weeks.
Use caution in patients with renal/hepatic impairment or reduced CYP2C19 activity.

Interactions

Additive CNS depression with alcohol, benzodiazepines, opioids, tricyclic antidepressants.
CYP2C19 inhibitors (e.g., omeprazole, fluvoxamine): increase exposure.
CYP2C19 inducers (e.g., rifampin): decrease exposure.

Contraindications

Side Effects Common: drowsiness, dizziness, headache.

Pregnancy & Lactation

Precautions & Warnings

Overdose Effects

CNS depression is common.
Severe cases: death, coma, respiratory depression, hypotension, seizures.
Management: supportive care, gastric lavage (within 1 hour), circulatory support, benzodiazepines for seizures, phenobarbital for recurrence, airway protection with intubation if needed.

Therapeutic Class Locally acting skeletal muscle relaxants.